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Nature Cell Biology (1)

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Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation

At sites of cell adhesion to the matrix, integrins are coupled to the actin cytoskeleton through proteins such as talin. Sun et al. now identify Kank2 as an activator of talin that reduces force transmission across focal adhesions.

Zhiqi Sun
Hui-Yuan Tseng
Reinhard Fässler
Research22 Aug 2016
Nature Cell Biology

Volume: 18, P: 941-953

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Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation

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