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Advanced filters: Author: Dirk Isbrandt Clear advanced filters

Treatment during a vulnerable developmental period rescues a genetic epilepsy

Treatment with the common diuretic bumetanide during a susceptible developmental window prevents epileptogenesis in a mouse model of a genetic epileptic encephalopathy.

Stephan Lawrence Marguet
Vu Thao Quyen Le-Schulte
Dirk Isbrandt
Research23 Nov 2015
Nature Medicine

Volume: 21, P: 1436-1444
Cardiac arrhythmia induced by genetic silencing of ‘funny’ (f) channels is rescued by GIRK4 inactivation

The ‘funny’ current (I_f) is important for the generation and regulation of the heart’s automaticity. Here the authors show that I_f silencing through genetic modification of the f-channel component HCN4 causes heart arrhythmia by altering Ca²⁺handling in pacemaker myocytes.

Pietro Mesirca
Jacqueline Alig
Matteo E. Mangoni
Research21 Aug 2014
Nature Communications

Volume: 5, P: 1-15
Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior

H Christian Peters
Hua Hu
Dirk Isbrandt
Research19 Dec 2004
Nature Neuroscience

Volume: 8, P: 51-60
Inhibition of G protein-gated K⁺ channels by tertiapin-Q rescues sinus node dysfunction and atrioventricular conduction in mouse models of primary bradycardia

Isabelle Bidaud
Antony Chung You Chong
Pietro Mesirca
ResearchOpen Access17 Jun 2020
Scientific Reports

Volume: 10, P: 1-13

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