Astrocytes drive multiple sclerosis (MS) by enhancing inflammation. Here, the authors show that the deubiquitinase OTUD7B in astrocytes protects mice from experimental autoimmune encephalomyelitis (EAE), a model of MS, by reducing inflammation and stabilizing GFAP thereby physically restricting inflammation.
- Kunjan Harit
- Wenjing Yi
- Dirk Schlüter
