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Showing 1–4 of 4 results
Advanced filters: Author: Dirk Tischler Clear advanced filters

  • Understanding how membrane-bound styrene oxide isomerase (SOI) catalyses the Meinwald rearrangement—a Lewis-acid-catalysed isomerization of an epoxide to a carbonyl compound—can be useful as SOI represents a green alternative to chemical synthesis. Here, the catalytic mechanism of SOI was determined using cryo-EM, EPR spectroscopy, mutagenesis, functional assays and docking experiments.

    • Basavraj Khanppnavar
    • Joel P. S. Choo
    • Xiaodan Li
    ResearchOpen Access
    Nature Chemistry
    Volume: 16, P: 1496-1504

  • Enzymes play an important role in organic synthesis thanks to their high selectivity, however, such selectivity limits their substrate scope and hampers their wide application. Here, the authors report an approach to rationally select enzymes with proposed functionalities based on sequence analysis, exploring the substrate scope of 4-phenol oxidases by in silico sequence-function correlation analysis.

    • Daniel Eggerichs
    • Nils Weindorf
    • Dirk Tischler
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-9

  • The freshwater cnidarian Hydra is a significant model for studies of axial patterning, stem cell biology and regeneration. Its (A+T)-rich genome has now been sequenced. Comparison of this genome with those of other animals provides insights into the evolution of epithelia, contractile tissues, developmentally regulated transcription factors, pluripotency genes and more.

    • Jarrod A. Chapman
    • Ewen F. Kirkness
    • Robert E. Steele
    ResearchOpen Access
    Nature
    Volume: 464, P: 592-596