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Showing 1–3 of 3 results
Advanced filters: Author: Djemel Hamdane Clear advanced filters

  • The bacterial thymidylate synthase ThyX catalyzes the reductive methylation of deoxyuridylate (dUMP) into deoxythymidylate (dTMP) and requires both folate and flavin for activity. Here, the authors combine biochemical experiments, spectroscopic measurements and flavin synthesis chemistry to show that formaldehyde (CH2O) can replace the natural methylene donor of ThyX in a CH2O-shunt reaction, yielding a carbinolamine intermediate with the reduced flavin coenzyme, and they present the crystal structure of this intermediate.

    • Charles Bou-Nader
    • Frederick W. Stull
    • Djemel Hamdane
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-8

  • Metal-organic frameworks are promising materials for proton exchange membrane fuel cells, but cumbersome ligand preparation and use of toxic metals or solvents hinders their application. Here, the authors report the green synthesis of a zirconium, amino acid-based MOF that displays high proton conductivity and excellent stability.

    • Sujing Wang
    • Mohammad Wahiduzzaman
    • Christian Serre
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-8