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Showing 1–2 of 2 results
Advanced filters: Author: Dmitry Grinfeld Clear advanced filters

  • Mass spectrometry-based thermal stability assays (MS-TSA) are a promising approach to characterize protein-ligand interaction, and several strategies have been recently developed to improve their performance. Here, the authors combine three recent strategies to qualitatively and quantitatively improve aspects of MS-TSA.

    • Clifford G. Phaneuf
    • Konstantin Aizikov
    • Alexander R. Ivanov
    ResearchOpen Access
    Communications Chemistry
    Volume: 6, P: 1-10

  • The high spatial resolution of secondary ion mass spectrometry and the high resolving power of the Orbitrap mass spectrometer are combined in a single imaging platform, the 3D OrbiSIMS. The instrument's capabilities for resolving lipids and neurotransmitters in the brain with subcellular spatial resolution, and a drug in a single cell in three dimensions is demonstrated.

    • Melissa K Passarelli
    • Alexander Pirkl
    • Ian S Gilmore
    Research
    Nature Methods
    Volume: 14, P: 1175-1183