Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–12 of 12 results
Advanced filters: Author: Dmitry Lyumkis Clear advanced filters

  • Li, Burgos-Bravo and colleagues report that NDF phase separation regulates FACT condensation, which enhances transcription by generating a localized biochemical environment that promotes nucleosome disassembly while preserving chromatin integrity by retaining histones.

    • Ziwei Li
    • Francesca Burgos-Bravo
    • Jia Fei
    ResearchOpen Access
    Nature Cell Biology
    P: 1-14

  • Here, the authors quantify the effect of cryo-EM data acquisition with stage-tilt on the global resolution of reconstructions and present a tool for predicting an optimal stage-tilt angle to ameliorate the effects of preferred specimen orientation.

    • Sriram Aiyer
    • Philip R. Baldwin
    • Dmitry Lyumkis
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • The formation of the 2′–5′ lariat bond during branching is the critical first step in RNA splicing. A structure of a group II intron reveals a conserved base triple responsible for positioning the adenosine nucleophile to attack the 5′ splice site.

    • Daniel B. Haack
    • Boris Rudolfs
    • Navtej Toor
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 179-189

  • Ribosome biogenesis is complex but efficient process in bacteria. Here the authors use cryo-electron microscopy and iterative hierarchical subclassification to identify intermediates in the assembly of the 50 S ribosomal subunit from E. coli.

    • Kai Sheng
    • Ning Li
    • James R. Williamson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10

  • Transcription-repair coupling factors (TRCFs) are large ATPases that mediate the preferential repair of the transcribed DNA strand. Here the authors reveal the cryo-EM structure of DNA-bound Mfd, the bacterial TRCF, and provide molecular insights into its mode of action.

    • Christiane Brugger
    • Cheng Zhang
    • Alexandra M. Deaconescu
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • The authors determined high-resolution cryo-EM structures of the lentiviral intasome — the nucleoprotein complex that inserts viral DNA into a host chromosome — and show that the architecture comprising 16 integrase subunits is critical for its function.

    • Allison Ballandras-Colas
    • Vidya Chivukula
    • Peter Cherepanov
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Single-particle cryo-EM is a powerful method for macromolecular structure determination. Here the authors demonstrate that Ewald sphere curvature correction, sub-Angstrom pixilation and per-particle CTF refinement can improve map quality and resolution and present the 1.86 Å cryo-EM structure of an adeno-associated virus serotype 2 variant.

    • Yong Zi Tan
    • Sriram Aiyer
    • Dmitry Lyumkis
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • New high-resolution cryo-electron microscopy structures of the HIV-1 envelope protein provide a detailed description and understanding of how the HIV-1 fusion machinery functions and how it changes its structure over time to convert from the pre-fusion to the fusion-intermediate conformation.

    • Gabriel Ozorowski
    • Jesper Pallesen
    • Andrew B. Ward
    Research
    Nature
    Volume: 547, P: 360-363

  • The preferred specimen orientation problem limits accuracy and resolution in structure determination by cryo-EM. Collecting data at defined sample tilts yielded near-atomic-resolution structures for the influenza hemagglutinin trimer and ribosomal biogenesis intermediates.

    • Yong Zi Tan
    • Philip R Baldwin
    • Dmitry Lyumkis
    Research
    Nature Methods
    Volume: 14, P: 793-796