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Showing 1–3 of 3 results
Advanced filters: Author: Dmytro Kryvokhyzha Clear advanced filters

  • Mulholland et al. identify progenitor exhausted T cells, expressing intermediate levels of PD-1 (PD-1int), as a prominent source of pro-inflammatory cytokines in the murine atherosclerotic aorta and potential cellular targets driving checkpoint inhibition-elicited pro-atherosclerotic immune responses. They further demonstrate elevated levels of circulating PD-1-expressing T cells in individuals with subclinical cardiovascular disease.

    • Megan Mulholland
    • Anthi Chalou
    • Daniel Engelbertsen
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 4, P: 1311-1328

  • Diabetic kidney disease is the leading cause of kidney failure in the world and cellular insulin resistance is an important driver of this disease. Here, Lay et al identify multiple insulin-resistance driven “common” and “cell-specific” kidney cell pathways and molecules that may be good therapeutic and biomarker targets.

    • Abigail C. Lay
    • Van Du T. Tran
    • Matthias Kretzler
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Genomic studies of Heliconius butterflies provide evidence that Heliconius elevatus is a hybrid species, and that its speciation was driven by introgression of traits from Heliconius melpomene into the other parent, an ancestor of Heliconius pardalinus.

    • Neil Rosser
    • Fernando Seixas
    • Kanchon K. Dasmahapatra
    ResearchOpen Access
    Nature
    Volume: 628, P: 811-817