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Showing 1–10 of 10 results
Advanced filters: Author: Dmytro Puchkov Clear advanced filters

  • Many bacterial toxins and viruses deform membranes prior to entering cells via clathrin independent endocytosis. Here the authors show that multivalent lipid binding by globular particles can exceed a threshold adhesion energy required for membrane deformation and that this is sufficient for internalization.

    • Raluca Groza
    • Kita Valerie Schmidt
    • Helge Ewers
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Stockhammer, Adarska et al. describe ARF1 compartments as the site of adaptor- and clathrin-dependent post-Golgi sorting. Shedding of ARF1 and maturation into recycling endosomes drives sorting of secretory and endocytic recycling cargo.

    • Alexander Stockhammer
    • Petia Adarska
    • Francesca Bottanelli
    ResearchOpen Access
    Nature Cell Biology
    Volume: 26, P: 1845-1859

  • Cells employ integrin-based adhesions with different molecular compositions to adhere to substrates. Here, the authors show that so-called “non-canonical” adhesions lacking focal adhesion components can convert to focal adhesions (and vice versa), through the selective exchange of components.

    • Fabian Lukas
    • Claudia Matthaeus
    • Tanja Maritzen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • The endocytic adaptor protein complex AP-2 is mostly known for its role in endocytosis and in synaptic vesicle reformation. Here the authors show that AP-2 also mediates retrograde transport of TrkB-containing autophagosomes in neurons; this process promotes neuronal complexity and prevents the degeneration of cortical and thalamic neurons.

    • Natalia L. Kononenko
    • Gala A. Claßen
    • Volker Haucke
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • Phosphoinositides are important regulators of intracellular membrane traffic, and although the role of PI(4,5)P2 has been well characterised, the function of PI(3,4)P2 remains unclear; here the formation of PI(3,4)P2 by the class II phosphatidylinositol-3-kinase C2α enzyme is shown to control clathrin-mediated endocytosis.

    • York Posor
    • Marielle Eichhorn-Gruenig
    • Volker Haucke
    Research
    Nature
    Volume: 499, P: 233-237

  • Synaptic inhibition in the olfactory bulb (OB) is believed to play a role in odour processing. Here, the authors use a Pcdh21-driven Cre-line to disrupt KCC2 expression in OB mitral cells and find altered synaptic connectivity along with disrupted separation of odour-induced activity patterns.

    • Kathrin Gödde
    • Olivier Gschwend
    • Thomas J. Jentsch
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • The precise mechanisms that cause human obesity remain unknown. Here the authors illustrate how increased expression of Cadm1, a mediator of synapse assembly, is relevant to weight gain. Reduction of Cadm1 in multiple brain regions promoted weight loss, and these observations provide insight into the neuronal pathways contributing to obesity.

    • Thomas Rathjen
    • Xin Yan
    • Matthew N Poy
    Research
    Nature Neuroscience
    Volume: 20, P: 1096-1103

  • A mechanism for phosphoinositide conversion at endosomes to enable exit from the endosomal system, suggesting that defective phosphoinositide conversion at endosomes underlies X-linked centronuclear myopathy.

    • Katharina Ketel
    • Michael Krauss
    • Volker Haucke
    Research
    Nature
    Volume: 529, P: 408-412