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Showing 1–5 of 5 results
Advanced filters: Author: Doc Reynolds Clear advanced filters

  • Whole-genome sequence data for 108 individuals representing 28 language groups across Australia and five language groups for Papua New Guinea suggests that Aboriginal Australians and Papuans diverged from Eurasian populations approximately 60–100 thousand years ago, following a single out-of-Africa dispersal and subsequent admixture with archaic populations.

    • Anna-Sapfo Malaspinas
    • Michael C. Westaway
    • Eske Willerslev
    Research
    Nature
    Volume: 538, P: 207-214

  • Here, the authors show that treatment with a monoclonal neutralizing antibody against the lung microbiota-derived proapoptotic peptide corisin ameliorates acute exacerbation of pulmonary fibrosis and severity of endotoxin-induced acute lung injury in mice.

    • Corina N. D’Alessandro-Gabazza
    • Taro Yasuma
    • Esteban C. Gabazza
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-23

  • Idiopathic pulmonary fibrosis is associated with increased abundance of Staphylococcus and Streptococcus in the lungs. Here, the authors identify a Staphylococcus nepalensis-derived peptide, named corisin, to induce apoptosis of lung epithelial cells and exacerbation of pulmonary fibrosis in mice.

    • Corina N. D’Alessandro-Gabazza
    • Tetsu Kobayashi
    • Esteban C. Gabazza
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • The custom microenvironment “vascular niche” is a potential therapeutic target for several pathophysiological conditions. Osteoblasts act as regulators of the hematopoietic stem cell niche, and activation of the parathyroid hormone (PTH) receptor may increase the number of cells mobilized into the bloodstream. The authors demonstrate that PTH may enhance the efficiency of hematopoietic stem cell-based therapy in a recognized model of peripheral ischemia.

    • Claudio Napoli
    • Sharon William-Ignarro
    • Louis J Ignarro
    Research
    Nature Clinical Practice Cardiovascular Medicine
    Volume: 5, P: 571-579

  • Imaging biomarkers (IBs) are used extensively in drug development and cancer research, but important differences exist between IBs and biospecimen-derived biomarkers. A tailored 'roadmap' is required for the development of new IBs to be used either in clinical research or for decision-making in healthcare. In this Consensus statement, a group of experts assembled by CRUK and the EORTC present 14 key recommendations for accelerating the clinical translation of IBs.

    • James P. B. O'Connor
    • Eric O. Aboagye
    • John C. Waterton
    ReviewsOpen Access
    Nature Reviews Clinical Oncology
    Volume: 14, P: 169-186