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Showing 1–3 of 3 results
Advanced filters: Author: Dominick Pierre-Jacques Clear advanced filters

  • NIPBL perturbation activates long terminal repeat (LTR)-derived alternative promoters due to reorganization of chromatin’s hierarchical structure, leading to LTR co-option and oncogene activation in melanoma cell lines.

    • Elissa W. P. Wong
    • Merve Sahin
    • Ping Chi
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 1754-1765

  • Locally elevated cholesterol in colorectal cancer cells with adenomatous polyposis coli truncation was observed to drive Wnt–β-catenin signaling through Dishevelled (Dvl). Inhibitors targeting the cholesterol–Dvl interaction potently suppress tumor growth without adverse side effects.

    • Ashutosh Sharma
    • Julian Zalejski
    • Wonhwa Cho
    Research
    Nature Chemical Biology
    Volume: 21, P: 1376-1386

  • Mass spectrometry imaging (MSI) is often limited by low spatial resolution. Here, the authors propose Gel-Assisted Mass Spectrometry Imaging (GAMSI), which enhances the spatial resolution of MALDI-MSI monitoring of lipids and proteins to the sub-micrometre level without changing existing hardware setups.

    • Yat Ho Chan
    • Koralege C. Pathmasiri
    • Ruixuan Gao
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12