Nature Search

Engineering light-inducible nuclear localization signals for precise spatiotemporal control of protein dynamics in living cells

Designing inducible and reversible nuclear localization signals would enable researchers to dissect and engineer cellular networks. Here Niopek et al.create a light-inducible nuclear localization signal to regulate gene expression and mitosis in mammalian cells, using blue light.

Dominik Niopek
Dirk Benzinger
Barbara Di Ventura
ResearchOpen Access14 Jul 2014
Nature Communications

Volume: 5, P: 1-11
Optogenetic control of nuclear protein export

Light-inducible control of protein subcellular localization holds great promise for synthetic biology applications and insights into basic cell biology. Here the authors develop a genetically-encoded light-inducible nuclear export system and apply it to a synthetic repressor and p53 transcriptional activity.

Dominik Niopek
Pierre Wehler
Barbara Di Ventura
ResearchOpen Access08 Feb 2016
Nature Communications

Volume: 7, P: 1-9
Guiding questions to avoid data leakage in biological machine learning applications

This Perspective discusses the issue of data leakage in machine learning based models and presents seven questions designed to identify and avoid the problems resulting from data leakage.

Judith Bernett
David B. Blumenthal
Markus List
Reviews09 Aug 2024
Nature Methods

Volume: 21, P: 1444-1453
AAV vector-mediated in vivo reprogramming into pluripotency

In vivo reprogramming of somatic cells is hampered by the need for vectors to express the OKSM factors in selected organs. Here the authors report new AAV-based vectors capable of in vivo reprogramming at low doses.

Elena Senís
Lluc Mosteiro
Dirk Grimm
ResearchOpen Access09 Jul 2018
Nature Communications

Volume: 9, P: 1-14
Computational design of anti-CRISPR proteins with improved inhibition potency

Domain insertion into the loop region of AcrIIC1 leads to a variant with enhanced inhibitory activity toward Neisseria meningitides Cas9, while structure-guided design turns AcrIIC1 into a potent inhibitor of Staphylococcus aureus Cas9.

Jan Mathony
Zander Harteveld
Dominik Niopek
Research13 Apr 2020
Nature Chemical Biology

Volume: 16, P: 725-730
The Somatic Mosaicism across Human Tissues Network

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Tim H. H. Coorens
Ji Won Oh
Yuqing Wang
Reviews02 Jul 2025
Nature

Volume: 643, P: 47-59
The combined effect of decreased stomatal density and aperture increases water use efficiency in maize

Larissa Barl
Betina Debastiani Benato
Viktoriya Avramova
ResearchOpen Access21 Apr 2025
Scientific Reports

Volume: 15, P: 1-11
Rapid growth of new atmospheric particles by nitric acid and ammonia condensation

Measurements in the CLOUD chamber at CERN show that the rapid condensation of ammonia and nitric acid vapours could be important for the formation and survival of new particles in wintertime urban conditions, contributing to urban smog.

Mingyi Wang
Weimeng Kong
Neil M. Donahue
ResearchOpen Access13 May 2020
Nature

Volume: 581, P: 184-189
The AIMe registry for artificial intelligence in biomedical research

We present the AIMe registry, a community-driven reporting platform for AI in biomedicine. It aims to enhance the accessibility, reproducibility and usability of biomedical AI models, and allows future revisions by the community.

Julian Matschinske
Nicolas Alcaraz
David B. Blumenthal
Comments & Opinion25 Aug 2021
Nature Methods

Volume: 18, P: 1128-1131
Engineered anti-CRISPR proteins for optogenetic control of CRISPR–Cas9

CASANOVA uses LOV and blue light to regulate CRISPR activity.

Felix Bubeck
Mareike D. Hoffmann
Dominik Niopek
Research30 Oct 2018
Nature Methods

Volume: 15, P: 924-927
Prediction of human population responses to toxic compounds by a collaborative competition

Crowdsourcing analysis improves computational prediction of cytotoxic responses in humans.

Federica Eduati
Lara M Mangravite
Julio Saez-Rodriguez
ResearchOpen Access01 Sept 2015
Nature Biotechnology

Volume: 33, P: 933-940
HeliantHOME, a public and centralized database of phenotypic sunflower data

Natalia Bercovich
Nikita Genze
Dominik G. Grimm
ResearchOpen Access30 Nov 2022
Scientific Data

Volume: 9, P: 1-9
Influence of AAV vector tropism on long-term expression and Fc-γ receptor binding of an antibody targeting SARS-CoV-2

This study compares a muscle-specific and a liver-specific AAV-vector capsid for the long-term delivery of a monoclonal antibody against SARS-CoV-2 in terms of longevity, protection against infection and influence on the glycosylation profile.

Jannik T. Wagner
Sandra M. Müller-Schmucker
Klaus Überla
ResearchOpen Access16 Jul 2024
Communications Biology

Volume: 7, P: 1-15
Correlation between structural heart disease and cardiac SARS-CoV-2 manifestations

Nägele, Graber et al. evaluate cardiac manifestations of SARS-CoV-2 in patients with structural heart disease. The authors find that detection of SARS-CoV-2 in heart tissue is associated with poorer survival.

Felix Nägele
Michael Graber
Can Gollmann-Tepeköylü
ResearchOpen Access11 Nov 2022
Communications Medicine

Volume: 2, P: 1-8
Manually annotated and curated Dataset of diverse Weed Species in Maize and Sorghum for Computer Vision

Nikita Genze
Wouter K. Vahl
Dominik G. Grimm
ResearchOpen Access23 Jan 2024
Scientific Data

Volume: 11, P: 1-10
Functional connectivity signatures of major depressive disorder: machine learning analysis of two multicenter neuroimaging studies

Selene Gallo
Ahmed El-Gazzar
Guido van Wingen
ResearchOpen Access15 Feb 2023
Molecular Psychiatry

Volume: 28, P: 3013-3022
Negative optokinetic afternystagmus in larval zebrafish demonstrates set-point adaptation

Ting-Feng Lin
Mohammad Mohammadi
Melody Ying-Yu Huang
ResearchOpen Access13 Dec 2019
Scientific Reports

Volume: 9, P: 1-14

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