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Deciphering the allosteric regulation of mycobacterial inosine-5′-monophosphate dehydrogenase

Here, Bulvas et al use biochemical and cryo-EM techniques to profile the regulatory mechanisms of the essential mycobacterial enzyme IMPDH. They show how GTP and (p)ppGpp nucleotides inhibit IMPDH by locking it in an inactive state.

Ondřej Bulvas
Zdeněk Knejzlík
Iva Pichová
ResearchOpen Access06 Aug 2024
Nature Communications

Volume: 15, P: 1-14
Outer membrane and phospholipid composition of the target membrane affect the antimicrobial potential of first- and second-generation lipophosphonoxins

Klára Látrová
Noemi Havlová
Gabriela Mikušová
ResearchOpen Access17 May 2021
Scientific Reports

Volume: 11, P: 1-16
Novel lipophosphonoxin-loaded polycaprolactone electrospun nanofiber dressing reduces Staphylococcus aureus induced wound infection in mice

Duy Dinh Do Pham
Věra Jenčová
Peter Gál
ResearchOpen Access03 Sept 2021
Scientific Reports

Volume: 11, P: 1-15
Molecular mutagenesis of ppGpp: turning a RelA activator into an inhibitor

Jelena Beljantseva
Pavel Kudrin
Vasili Hauryliuk
ResearchOpen Access03 Feb 2017
Scientific Reports

Volume: 7, P: 1-10
LEGO-Lipophosphonoxin membrane activity is enhanced by presence of phosphatidylethanolamine but hindered by outer membrane

Hana Brzobohatá
Milica Dugić
Gabriela Mikušová
ResearchOpen Access07 Jan 2025
Scientific Reports

Volume: 15, P: 1-18