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Trifunctional sphingomyelin derivatives enable nanoscale resolution of sphingomyelin turnover in physiological and infection processes via expansion microscopy

The enzymatic breakdown of the lipid sphingomyelin is associated with various infectious diseases. Here, the authors introduce trifunctional sphingomyelin derivatives for the visualisation of sphingomyelin distribution and sphingomyelinase activity in infection processes.

Marcel Rühling
Louise Kersting
Jürgen Seibel
ResearchOpen Access28 Aug 2024
Nature Communications

Volume: 15, P: 1-16
Auto-aggressive CXCR6⁺ CD8 T cells cause liver immune pathology in NASH

Liver resident CD8 T cells have an essential role in immunopathology in a mouse model of nonalcoholic steatohepatitis, by becoming auto-aggressive following sequential transcriptional and metabolic activation steps .

Michael Dudek
Dominik Pfister
Percy A. Knolle
Research24 Mar 2021
Nature

Volume: 592, P: 444-449
Author Correction: Auto-aggressive CXCR6⁺ CD8 T cells cause liver immune pathology in NASH

Michael Dudek
Dominik Pfister
Percy A. Knolle
Amendments and Corrections10 May 2021
Nature

Volume: 593, P: E14

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