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Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Amendments and CorrectionsOpen Access12 Jan 2022
Nature Medicine

Volume: 28, P: 212
Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation

Here the authors report 20 novel genomic risk loci for calcific aortic valve stenosis, the most common heart valve disorder. Using RNA sequencing in 500 human aortic valves, they prioritize candidate causal genes including TWIST1, a gene involved in endothelial-mesenchymal transition.

Sébastien Thériault
Zhonglin Li
Yohan Bossé
ResearchOpen Access18 Mar 2024
Nature Communications

Volume: 15, P: 1-14
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

Philippe Bégin
Jeannie Callum
Donald M. Arnold
ResearchOpen Access09 Sept 2021
Nature Medicine

Volume: 27, P: 2012-2024
Appraisal of multiple polygenic risk scores to estimate the risk of myocardial infarction and coronary artery lesions

Manikpurage et al. evaluate the association between existing polygenic risk scores (PRS) and myocardial infarction (MI) as well as the extent of coronary artery lesions at coronary angiography. The combination of several PRS could improve risk estimation of MI, extent and recurrence of atherosclerotic coronary lesions.

Hasanga D. Manikpurage
Jérôme Bourgault
Sébastien Thériault
ResearchOpen Access01 Jul 2025
Communications Medicine

Volume: 5, P: 1-12
Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance

Sodium/proton exchangers (NHEs) are critical regulators of pH within the cell and the extracellular microenvironment. Here, the authors show that hypoxia induces mobilization of NHE6 from endosomal compartment to the plasma membrane in a PKC-dependent manner inducing hyper acidification of endosomes and drug resistance.

Fabrice Lucien
Pierre-Paul Pelletier
Claire M. Dubois
ResearchOpen Access21 Jun 2017
Nature Communications

Volume: 8, P: 1-15
Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Research10 Jan 2022
Nature Medicine

Volume: 28, P: 53-58

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Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Appraisal of multiple polygenic risk scores to estimate the risk of myocardial infarction and coronary artery lesions

Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance

Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

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