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Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism

Schell et al. demonstrate that inactivation of the mitochondrial pyruvate carrier in mouse and fly intestinal stem cells (ISCs) locks the cell into a glycolytic metabolic program and promotes the expansion of the stem cell compartment.

John C. Schell
Dona R. Wisidagama
Jared Rutter
Research14 Aug 2017
Nature Cell Biology

Volume: 19, P: 1027-1036
The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus–induced microRNAs

Polymorphisms near genes encoding members of the IFN-λ family are associated with susceptibility or resistance to hepatitis C virus. Savan and colleagues show that differences in the stability of transcripts of those genes underlie the mechanism of resistance to that virus.

Adelle P McFarland
Stacy M Horner
Ram Savan
Research17 Nov 2013
Nature Immunology

Volume: 15, P: 72-79
Bcl2 is a critical regulator of bile acid homeostasis by dictating Shp and lncRNA H19 function

Yuxia Zhang
Chune Liu
Li Wang
ResearchOpen Access03 Feb 2016
Scientific Reports

Volume: 6, P: 1-11
RAGE is a Critical Mediator of Pulmonary Oxidative Stress, Alveolar Macrophage Activation and Emphysema in Response to Cigarette Smoke

Karl A. Sanders
Don A. Delker
John R. Hoidal
ResearchOpen Access18 Jan 2019
Scientific Reports

Volume: 9, P: 1-16

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