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Showing 1–4 of 4 results
Advanced filters: Author: Donal Hollywood Clear advanced filters
  • In this Review, Marignol and colleagues evaluate the potential involvement of hypoxia in the deregulated expression of notch receptors, ligands, and targets in prostate cancer cells and consider the likely involvement of hypoxia and notch signalling in disease progression, treatment resistance, and the identification of novel therapeutic targets for prostate cancer.

    • Laure Marignol
    • Karla Rivera-Figueroa
    • Donal Hollywood
    Reviews
    Nature Reviews Urology
    Volume: 10, P: 405-413
  • Epigenetic changes, such as gain and loss of DNA methylation and altered histone modifications, are a hallmark of human cancer. The role of the epigenome in prostate cancer is well recognized. In this Review, the authors discuss the different epigenetic modifications which can contribute to cancer progression, and consider the therapeutic potential of targeting the epigenome in patients with prostate cancer.

    • Antoinette S. Perry
    • R. William G. Watson
    • Donal Hollywood
    Reviews
    Nature Reviews Urology
    Volume: 7, P: 668-680
  • MicroRNAs (miRNAs) have been implicated in prostate cancer initiation and progression, as well as response to cancer treatment. Here, O'Kelly and colleagues describe the basics of miRNA biology before discussing the available data on the role of miRNAs in the response of prostate tumours to hormone therapy, chemotherapy and radiation therapy.

    • Fardod O'Kelly
    • Laure Marignol
    • Donal Hollywood
    Reviews
    Nature Reviews Urology
    Volume: 9, P: 397-407
  • Pablo Carbonell et al. present an automated pipeline for the discovery and optimization of biosynthetic pathways for microbial production of fine chemicals. They apply their pipeline to the production of the flavonoid (2S)-pinocembrin in Escherichia coli and show improvement of the pathway by 500-fold.

    • Pablo Carbonell
    • Adrian J. Jervis
    • Nigel S. Scrutton
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-10