Passive transfer of high doses of neutralizing antibodies can protect nonhuman primates against infection with simian HIV (SHIV). Ng et al. now report that low levels of neutralizing polyclonal antibodies plus a neutralizing monoclonal antibody do not prevent infection with SHIV, but do delay peak viremia, modulate CD4+ T cell decline and promote the de novo generation of neutralizing antibodies in macaques.
- Cherie T Ng
- J Pablo Jaworski
- Nancy L Haigwood
