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Ethylene is synthesized from the non-proteinogenic amino acid ACC. Here, Mou et al. show that ACC itself acts independently of ethylene to trigger secretion of a pollen tube attractant in the sporophytic tissue of Arabidopsis ovules and can activate Ca²⁺-currents via GLUTAMATE RECEPTOR-LIKE channels.

A study reports data from the first phase of the Chinese Pangenome Consortium including 116 de novo assemblies from 58 core samples representing 36 minority Chinese ethnic groups.

To possess a small singlet-triplet energy gap and a large oscillator strength simultaneously is critical for efficient thermally activated delayed fluorescent emitters. Here, the authors attach an multiresonance-acceptor onto a sterically-uncrowded donor for realizing a device efficiency of 40.4%.

Heterogeneous populations of basal cells in the prostate epithelium contain stem cells. Here the authors show that Zeb1 marks a pool of prostate epithelial stem cells that self-renew, generate prostate glandular structures with all 3 epithelial cell types and are required for prostate basal cell development.

Due to the polygenic nature of most diseases, simultaneous correction or introduction of single nucleotide variants is needed. Here, the authors demonstrated the feasibility of multiplex base editing for polygenes disease modeling in cynomolgus monkey embryos with high specificity.

Chromosome-scale sequence assemblies of 20 diverse varieties of barley are used to construct a first-generation pan-genome, revealing previously hidden genetic variation that can be used by studies aimed at crop improvement

Design of artificial catalysts to mimic enzyme activity and selectivity is a challenge in the catalysis field. Here, the authors design a platinum catalyst with a porous cage ligand which shows enzyme-like properties, such as high hydrosilylation activity and substrate size selectivity, while being recyclable.

Magnetic random access memory (MRAM) exhibits remarkable device endurance, while also offering potential operation speed and energy efficiency improvements compared to conventional random access memory. However, challenges remain, both in terms of efficiency, and miniaturization. Here, Wang et al demonstrate a van der Waals (vdW) based spin-orbit torque switching, in a Fe₃GeTe₂/Bi2Te₃ heterostructure, paving the way for thinner and higher efficiency spin-orbit torque based vdW MRAM.

Lymphatic metastases are closely associated with tumor relapse and reduced survival in colorectal cancer (CRC). Here, the authors analysed the primary tumours, lymph node metastasis and liver metastasis of ten CRC patients and reveal co-existence of diverse modes of metastasis in the same patient.

The understanding of the structure-property relationship of mechanochromic luminescent molecules remains challenging. Here, the authors elucidate the effect of host-guest interactions on the mechanochromic properties of organic molecules.

Respiratory syncytial virus (RSV) is a pathogenic non-segmented negative-sense RNA virus and active RSV polymerase is composed of a 250 kDa large (L) protein and tetrameric phosphoprotein (P). Here, the authors present the 3.67 Å cryo-EM structure of the RSV polymerase (L:P) complex.

GDF15 treatment in mice counteracts compensatory reductions in energy expenditure, resulting in greater weight loss and reductions in non-alcoholic fatty liver disease compared to caloric restriction alone.

Designing efficient selector devices remains a challenge. Here, the authors propose a CuAg alloy-based selector with excellent ON/OFF ratio and thermal stability. It can effectively suppress the sneak-path current in 1S1R arrays, making it suitable for storage class memory and neuromorphic computing applications.

Engineering metastability can enhance the ductility of alloys, but it often comes at an expense of relatively low yield strength. Here, the authors fabricate a Ti-based alloy with heterogeneous laminated structures and α-nanoprecipitates that enhance yield strength without sacrificing ductility.

Small RNA-binding ARGONAUTE proteins are important regulators of gene silencing and plant development. Here Zhang et al. identify conserved motifs in ArabidopsisARGONAUTE proteins that determine binding to specific microRNA duplex structures.

To date the performance of molecular electronics compared to silicon limits their applications. Yang et al. develop the first mechano-optoelectronic switch based on mechanically controlled aggregation-induced emission of the self-assembled molecules, which can be reversibly switched at high speed.

The success of a fluorescent dye as a molecular probe to monitor the intracellular activity of biomolecules depends on its physicochemical characteristics. Here, the authors use a predictive model to identify key features that allow them to design cell permeable, background-free fluorescent probes.

The structure of nanoparticles strongly influences their properties. Here, the authors use single crystal X-ray diffraction to resolve the crystal structures of Ag₁₃₆ and Ag₃₇₄nanoparticles, enabling the observation of local structure distortion and the lower size limit of surface plasmon resonance.

Gut microbiome has been linked to cavernous angioma (CA), a common vascular disease, but the role in humans remains unclear. Here, the authors combine 16S rRNA sequencing and shotgun metagenomics to profile the microbiome in a large cohort of human subjects with and without CA, and among subjects with different CA clinical features.

It is challenging to obtain Ti alloys with ultrafine microstructure owing to the low thermal stability of crystallographic boundaries. Here the authors demonstrate a chemical boundary-based strategy to produce a hierarchical Ti alloy with nano-martensites that has excellent strength and ductility.

Varying growth temperatures enables the tuning of the degree of disorder, which is fully described by the absence/presence of medium-range order and temperature-dependent densities of nanocrystallites, and electrical conductivity in amorphous monolayer carbon films.

Yang, Chen et al. present ModVAR, a multimodal tool that integrates DNA sequence, protein structure, and cancer omics to predict cancer driver variants. It performs strongly on validated benchmarks, flags potentially actionable variants supported by docking, and models changes in intrinsically disordered protein regions.

Earth System Models are widely used for projecting future streamflow. The authors show that the models underestimate declines in global streamflow with climate change, indicating that a future water crisis could be more severe than previously estimated.

The authors have developed an adaptive reinforced dynamics approach, which improves the efficiency when exploring the configurational space and free energy landscape of large biomolecules, such as proteins.

Hydrogen production from water electrolysis requires high working voltages and produces H₂ only at the cathode. Now, H₂ generation during the oxidation of biomass-derived aldehydes is combined with the hydrogen evolution reaction on the cathode for low-voltage H₂ production.

Fabrication of perovskite-polymer composites that simultaneously possesses strong mechanical strength, high stretchability, high stability towards harsh aqueous environments and self-healing properties is challenging. Here, the authors report a luminescent composite that is simultaneously transparent, tough and can autonomously self-heal in both dry and wet conditions.

Favoured cathodes for batteries should include abundant and redox-active elements, such as manganese. Here the authors report a Na_0.6Li_0.2Mn_0.8O₂ cathode design featuring a unique layer stacking sequence that provides topological protection to oxygen redox to overcome the performance fading.

Here, the authors show that enhanced tropical cyclone activity was synchronized with increased Asian dust emissions during the Little Ice Age, implying a mechanism linking tropical cyclone climatology to Asian dust levels, at 100 to 1000 year scales.

Rapid growth of highly crystalline Covalent organic framework (COF) materials remains challenging. Here, the authors accelerate single-crystal polymerization using supercritical CO2 and realize the fabrication of two-dimensional COF single crystals within several minutes.

A statistical modeling method is proposed to generalize right censored data to a standard regression problem, thus making it possible to apply regression learning algorithms to survival prediction problems.

MAPK signaling suppresses autoimmunity mediated by the SUMM2 receptor in Arabidopsis. Here Huang et al. show that a trimeric complex consisting of the GPI anchored protein LLG1, and the two receptor-like proteins LET1 and LET2, promotes activation of SUMM2 according to MAPK signaling status.

By focusing a sub-relativistic infrared laser pulse onto a silica target, a periodic deflection pattern of attosecond electron pulse trains is observed. It reveals these subcycle charge dynamics with a streaking speed of ~60 μrad as⁻¹.

The generation of induced pluripotent stem cells might be improved by replacing the reprogramming transgenes with small molecules. To provide cells suitable for small-molecule screening, Markoulaki et al. segregate the transgenes Oct4, Sox2, Klf4 and c-Myc through breeding, creating mice carrying all possible combinations of the four factors.

Defect density reduction is pertinent for halide perovskite solar cells but a universal strategy has not been exploited. Here Chen et al. show that by fine tuning the alkaline environment in precursor solution, they can greatly suppress defects density and obtain high certified efficiency of 20.87%.

Viruses rely on host cell metabolism for replication, making these pathways potential therapeutic targets. Here, the authors show that AM580, a retinoid derivative and RAR-α agonist, affects replication of several RNA viruses by interfering with the activity of SREBP.

The CRISPR–Cas9-mediated generation of germline-transmissible mutations of SHANK3 in cynomolgus macaques (Macaca fascicularis) forms the basis of a non-human-primate model of autism spectrum disorder and Phelan–McDermid syndrome.

Designed tetrameric peptide bundles covalently connected end-to-end yield rigid, semiflexible and kinked chains, as well as hydrogel networks, providing a platform for synthetic biomaterials.

Aqueous solutions under nanoscale confinement exhibit interesting physicochemical properties. This work reports evidence on the spontaneous formation of two-dimensional alkali chloride crystalline/non-crystalline nanostructures in dilute aqueous solution under nanoscale confinement by computer simulations.

Analysis of genotyping-by-sequencing data for more than 20,000 barley accessions from a German genebank provides a framework for genomics-assisted genebank management and analysis of large germplasm collections for important crops.

TNS1, a focal adhesion protein that is upregulated during TGFβ -induced EMT, promotes metastasis of lung cancer via forming a positive feed-back loop with ZEB1, leading to ZEB1 upregulation by preventing its ubiquitin-proteasomal degradation.

Electric-field modulation of magnetic properties in 2D magnets could be a potential route to develop energy-efficient spintronic devices. This study demonstrates that piezoelectric strain induced by electric fields can modulate atomic bonds in Fe₃GaTe₂ flakes, affecting their electronic band structure close to the Fermi level and leading to a substantial change in magnetic anisotropy.

Li and colleagues show how cMyc promotes tumourigenesis by promoting succinate dehydrogenase complex subunit A acetylation by activating SKP2-mediated degradation of SIRT3. This leads to succinate accumulation and consequent tumour-specific gene expression.

The mammalian stomach is a complex organ with diverse roles in health and disease. Here, the authors integrate proteomics and transcriptomics to analyze the mouse stomach at 15 time points during development, providing molecular level insights into system-wide developmental changes.

Functional materials displaying tunable emission and long-lived luminescence are a powerful tool in information encryption, organic electronics and bioelectronics. Here the authors design a color-tunable ultralong organic room temperature phosphorescence polymer through radical multiple component cross-linked copolymerization.