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Showing 1–4 of 4 results
Advanced filters: Author: Doris A. van Bergeijk Clear advanced filters

  • Actinobacteria are versatile producers of bioactive natural products. In this Review, van Wezel and colleagues discuss ecological and genomic insights into the mechanisms governing natural product metabolism and how those insights can be translated into approaches for computational and experimental genome mining strategies that yield novel bioactive molecules, in particular antibiotics.

    • Doris A. van Bergeijk
    • Barbara R. Terlouw
    • Gilles P. van Wezel
    Reviews
    Nature Reviews Microbiology
    Volume: 18, P: 546-558

  • Advances in computational omics technologies are enabling access to the hidden diversity of natural products, and artificial intelligence approaches are facilitating key steps in harnessing the therapeutic potential of such compounds, including biological activity prediction. This article discusses synergies between these fields to effectively identify drug candidates from the plethora of molecules produced by nature, and how to address the challenges in realizing the potential of these synergies.

    • Michael W. Mullowney
    • Katherine R. Duncan
    • Marnix H. Medema
    Reviews
    Nature Reviews Drug Discovery
    Volume: 22, P: 895-916

  • Microbial natural products are an important source for antibiotic discovery, however, their efficient dereplication remains challenging. Here, the authors develop an analytical pipeline, nanoRAPIDS, to prioritize low abundance bioactive compounds at nanoscale, by integrating the bioassay of interest, automated mass spectrometry identification and GNPS-based dereplication, resulting in the discovery of saquayamycin N from Streptomyces sp. MBT84.

    • Isabel Nuñez Santiago
    • Nataliia V. Machushynets
    • Gilles P. van Wezel
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-10

  • The biosynthetic gene clusters of Actinobacteria are poorly expressed in the laboratory, necessitating a better understanding of the signals that promote their expression in order to exploit their full biosynthetic potential. Here, the authors show that the stress hormone epinephrine elicits the expression of biosynthetic gene clusters and influences the metabolism of Streptomyces, with the catechol moiety proving key to this response.

    • Doris A. van Bergeijk
    • Somayah S. Elsayed
    • Gilles P. van Wezel
    ResearchOpen Access
    Communications Chemistry
    Volume: 5, P: 1-12