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Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion

Group B Streptococcus (GBS) causes neonatal disease and mortality worldwide. Here, the authors use genome-wide association analyses to identify bacterial genetic signatures associated with disease onset time and meningeal tissue infection in acute invasive neonatal GBS disease.

Chrispin Chaguza
Dorota Jamrozy
Stephen D. Bentley
ResearchOpen Access21 Jul 2022
Nature Communications

Volume: 13, P: 1-13
Author Correction: Genomics and epidemiological surveillance

Stephanie W. Lo
Dorota Jamrozy
Amendments and Corrections28 Jul 2020
Nature Reviews Microbiology

Volume: 18, P: 539
Looking at Beijing's skyline

This month's Genome Watch explores recent findings on the global population structure and the origin of the successfulMycobacterium tuberculosisBeijing lineage revealed by high-throughput sequencing of global bacterial collections.

Dorota Jamrozy
Teemu Kallonen
News10 Aug 2015
Nature Reviews Microbiology

Volume: 13, P: 528
The mutational landscape of Staphylococcus aureus during colonisation

The authors applied a genomic and evolutionary approach to study Staphylococcus aureus in host adaptation during colonisation revealing signals of adaption in metabolic genes, in regulators of quorum-sensing and in known antibiotic targets.

Francesc Coll
Beth Blane
Ewan M. Harrison
ResearchOpen Access13 Jan 2025
Nature Communications

Volume: 16, P: 1-15
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era

Enterococcus faecalis is a commensal microorganism of animals, insects and humans, but also a nosocomial pathogen. Here, the authors analyse genomic sequences from E. faecalis isolates from animals and humans, and find that the last common ancestors of multiple hospital-associated lineages date to the pre-antibiotic era.

Anna K. Pöntinen
Janetta Top
Jukka Corander
ResearchOpen Access09 Mar 2021
Nature Communications

Volume: 12, P: 1-13
Genomic identification of cryptic susceptibility to penicillins and β-lactamase inhibitors in methicillin-resistant Staphylococcus aureus

Collateral sensitivity-inducing mutations in methicillin-resistant Staphylococcus aureus strains lead to re-sensitization of bacteria to penicillin–clavulanic acid combinatorial treatment.

Ewan M. Harrison
Xiaoliang Ba
Mark A. Holmes
Research24 Jun 2019
Nature Microbiology

Volume: 4, P: 1680-1691
Genomics and epidemiological surveillance

This month’s Genome Watch highlights how genomic surveillance can provide important information for identifying and tracking emerging pathogens such as SARS-CoV-2.

Stephanie W. Lo
Dorota Jamrozy
News20 Jul 2020
Nature Reviews Microbiology

Volume: 18, P: 478
Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

Post-international travel quarantine has been widely implemented to mitigate SARS-CoV-2 transmission, but the impacts of such policies are unclear. Here, the authors used linked genomic and contact tracing data to assess the impacts of a 14-day quarantine on return to England in summer 2020.

Dinesh Aggarwal
Andrew J. Page
Ewan M. Harrison
ResearchOpen Access23 Feb 2022
Nature Communications

Volume: 13, P: 1-13
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

Dinesh Aggarwal
Ben Warne
Ian G. Goodfellow
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-16
Increasing incidence of group B streptococcus neonatal infections in the Netherlands is associated with clonal expansion of CC17 and CC23

Dorota Jamrozy
Merijn W. Bijlsma
Stephen D. Bentley
ResearchOpen Access12 Jun 2020
Scientific Reports

Volume: 10, P: 1-13
Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England

Genetic and testing data from England show that the SARS-CoV-2 variant of concern B.1.1.7 has a transmission advantage over other lineages.

Erik Volz
Swapnil Mishra
Neil M. Ferguson
Research25 Mar 2021
Nature

Volume: 593, P: 266-269
Genomic reconstruction of the SARS-CoV-2 epidemic in England

A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
ResearchOpen Access14 Oct 2021
Nature

Volume: 600, P: 506-511
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E23
Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
Amendments and CorrectionsOpen Access07 Jun 2022
Nature

Volume: 606, P: E18

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Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion

Author Correction: Genomics and epidemiological surveillance

Looking at Beijing's skyline

The mutational landscape of Staphylococcus aureus during colonisation

SARS-CoV-2 evolution during treatment of chronic infection

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era

Genomic identification of cryptic susceptibility to penicillins and β-lactamase inhibitors in methicillin-resistant Staphylococcus aureus

Genomics and epidemiological surveillance

Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

Increasing incidence of group B streptococcus neonatal infections in the Netherlands is associated with clonal expansion of CC17 and CC23

Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England

Genomic reconstruction of the SARS-CoV-2 epidemic in England

Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

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