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Advanced filters: Author: Dorottya Csuka Clear advanced filters
  • As the first national network of early-career researchers marks its 21st birthday, the founders of Hungary’s describe how and why they set up theirs in 2019.

    • Erika Bálint
    • Dorottya Csuka
    • Katalin Solymosi
    Comments & Opinion
    Nature
    Volume: 594, P: 599-601
  • Stereoselective production of trans-4-substituted cyclohexane-1-amines—including a key intermediate in the synthesis of antipsychotic drug cariprazine—remains challenging. Here, the authors develop a process catalyzed by a single transaminase to produce trans-4-substituted cyclohexane-1-amines from the corresponding cis/trans-diastereomeric mixtures via a cis-deamination approach in continuous-flow, to achieve a dynamic cis-to-trans isomerization.

    • Emese Farkas
    • Péter Sátorhelyi
    • János Éles
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-9