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Advanced filters: Author: Douglas Sammon Clear advanced filters

  • Designed heterotrimers of collagen I, locked in three possible chain registers, enable structural and functional characterization of each permutation, leading to identification of the AAB heterotrimer as the most active and therefore likely to occur biologically.

    • Abhishek A. Jalan
    • Douglas Sammon
    • Richard W. Farndale
    Research
    Nature Chemical Biology
    Volume: 16, P: 423-429

  • Heparan sulfate (HS) and chondroitin sulfate (CS) are different glycosaminoglycan chains that are attached to core proteins via the same linker tetrasaccharide, and it was unclear how core proteins are specifically modified with HS or CS. Here, the authors determine that the CS-initiating glycosyltransferase CSGALNACT2 is promiscuous, whereas the HS-initiating glycosyltransferase EXTL3 selects only certain core proteins for modification.

    • Douglas Sammon
    • Anja Krueger
    • Erhard Hohenester
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13