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Showing 1–2 of 2 results
Advanced filters: Author: Duco van Dalen Clear advanced filters

  • Deubiquitinating enzymes (DUBs) are critical regulators of cellular processes by removing ubiquitin from specific targets. Here global kinetic modelling reveals the mechanism by which the low intrinsic activity of USP7 is substantially enhanced on a specific physiological target.

    • Robbert Q. Kim
    • Paul P. Geurink
    • Titia K. Sixma
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • The interplay of the proteasome and deubiquitinase Ubp6 is crucial for the degradation of ubiquitylated substrates. Here, the authors provide structural insights into the allosteric mechanism by which the activities of both Ubp6 and the proteasome are regulated.

    • Ka Ying Sharon Hung
    • Sven Klumpe
    • Daniel Finley
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13