Nature Search

A retrospective cohort study of valproate and infertility in men with epilepsy or bipolar disorder using international health data

Valproate prescribing is being restricted in men due to animal studies linking it to infertility. Results in humans are conflicting. In this large study, men with epilepsy or bipolar disorder on valproate did not show a clear increase in infertility.

Gashirai K. Mbizvo
Susan E. Duncan
Anthony G. Marson
ResearchOpen Access15 Sept 2025
Nature Communications

Volume: 16, P: 1-17
Geological Climates

P. MARTIN DUNCAN
Research14 Oct 1880
Nature

Volume: 22, P: 559
Shared heritability and functional enrichment across six solid cancers

Similarities in cancers can be studied to interrogate their etiology. Here, the authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry, showing that solid tumours arising from different tissues share a degree of common germline genetic basis.

Xia Jiang
Hilary K. Finucane
Sara Lindström
ResearchOpen Access25 Jan 2019
Nature Communications

Volume: 10, P: 1-23
Ecological adaptation drives wood frog population divergence in life history traits

Emily H. Le Sage
Sarah I. Duncan
Erica J. Crespi
Research03 Feb 2021
Heredity

Volume: 126, P: 790-804
Transcriptional activity and strain-specific history of mouse pseudogenes

Pseudogenes are key markers of genome remodelling processes. Here the authors present genome-wide annotation of the pseudogenes in the mouse reference genome and 18 inbred mouse strains, update human pseudogene annotations, and characterise the transcription and evolution of mouse pseudogenes.

Cristina Sisu
Paul Muir
Mark Gerstein
ResearchOpen Access29 Jul 2020
Nature Communications

Volume: 11, P: 1-14
Deep formation of Earth’s earliest continental crust consistent with subduction

Early continental crust formed at depth, implying some type of plate tectonics operating as long as 4 billion years ago, according to high-pressure and temperature melting experiments of an analogue material.

Alan R. Hastie
Sally Law
Duncan D. Muir
ResearchOpen Access24 Aug 2023
Nature Geoscience

Volume: 16, P: 816-821
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

Dinesh Aggarwal
Ben Warne
Ian G. Goodfellow
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-16
Rapid discharge connects Antarctic subglacial lakes

Observation of surface elevation changes over 16 months in an area of the East Antarctic ice sheet overlying subglacial lakes suggests a rapid discharge of one lake to at least two other lakes, involving a water volume of 1.8 km³ — in conflict with previous expectations that subglacial lakes have long residence times and slow circulations.

Duncan J. Wingham
Martin J. Siegert
Alan S. Muir
Research01 Apr 2006
Nature

Volume: 440, P: 1033-1036
Impaired cell fate through gain-of-function mutations in a chromatin reader

The histone-acetylation-reader protein ENL is mutated in a paediatric kidney cancer in such a way that it clusters at target genes, increasing the recruitment of the transcriptional machinery, enhancing transcription and deregulating cell fate during development.

Liling Wan
Shasha Chong
C. David Allis
Research18 Dec 2019
Nature

Volume: 577, P: 121-126
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci

Sequence assemblies for the genomes of 16 widely used inbred laboratory mouse strains highlight considerable strain-specific haplotype variation and allow for the identification of regions with the greatest sequence diversity between strains.

Jingtao Lilue
Anthony G. Doran
Thomas M. Keane
ResearchOpen Access01 Oct 2018
Nature Genetics

Volume: 50, P: 1574-1583
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Sensitivity and specificity of blood-fluid levels for oral anticoagulant-associated intracerebral haemorrhage

Abeer Almarzouki
Duncan Wilson
David J. Werring
ResearchOpen Access23 Sept 2020
Scientific Reports

Volume: 10, P: 1-11
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

The Omicron variant evades vaccine-induced neutralization but also fails to form syncytia, shows reduced replication in human lung cells and preferentially uses a TMPRSS2-independent cell entry pathway, which may contribute to enhanced replication in cells of the upper airway. Altered fusion and cell entry characteristics are linked to distinct regions of the Omicron spike protein.

Brian J. Willett
Joe Grove
Emma C. Thomson
ResearchOpen Access07 Jul 2022
Nature Microbiology

Volume: 7, P: 1161-1179
Genomic reconstruction of the SARS-CoV-2 epidemic in England

A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
ResearchOpen Access14 Oct 2021
Nature

Volume: 600, P: 506-511
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

Better analytical methods are needed to extract biological meaning from genome-wide association studies (GWAS) of psychiatric disorders. Here the authors take GWAS data from over 60,000 subjects, including patients with schizophrenia, bipolar disorder and major depression, and identify common etiological pathways shared amongst them.

Colm O'Dushlaine
Lizzy Rossin
Gerome Breen
Research19 Jan 2015
Nature Neuroscience

Volume: 18, P: 199-209
Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders

Neurodevelopmental disorders (NDDs) are a heterogeneous group of diseases for which the genetic basis is still unknown in more than half of the cases. Here, the authors report a NDD associated with disruptive variants in the TANC2 gene and show that rols, the TANC2 homolog in flies, is required for synapse growth and function.

Hui Guo
Elisa Bettella
Evan E. Eichler
ResearchOpen Access15 Oct 2019
Nature Communications

Volume: 10, P: 1-17
A systematic global stocktake of evidence on human adaptation to climate change

Determining progress in adaptation to climate change is challenging, yet critical as climate change impacts increase. A stocktake of the scientific literature on implemented adaptation now shows that adaptation is mostly fragmented and incremental, with evidence lacking for its impact on reducing risk.

Lea Berrang-Ford
A. R. Siders
Thelma Zulfawu Abu
Research28 Oct 2021
Nature Climate Change

Volume: 11, P: 989-1000
Crystallographic and geochemical responses of giant clams on turbid reefs

Kimberley Mills
Sindia Sosdian
Zarinah Waheed
ResearchOpen Access02 Mar 2025
Scientific Reports

Volume: 15, P: 1-13
Publisher Correction: Shared heritability and functional enrichment across six solid cancers

Xia Jiang
Hilary K. Finucane
Sara Lindström
Amendments and CorrectionsOpen Access23 Sept 2019
Nature Communications

Volume: 10, P: 1-8
Plasma Exosome Profiling of Cancer Patients by a Next Generation Systems Biology Approach

Valeriy Domenyuk
Zhenyu Zhong
David Spetzler
ResearchOpen Access20 Feb 2017
Scientific Reports

Volume: 7, P: 1-15
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study

Kerstin Kläser
Erika Molteni
Emma L. Duncan
ResearchOpen Access28 Jun 2022
Scientific Reports

Volume: 12, P: 1-17
IFITM3 restricts the morbidity and mortality associated with influenza

Interferon-inducible transmembrane (IFITM) protein 3 is shown to be an innate defence mechanism against viral infection in vivo; furthermore, a subset of the patients hospitalized during the H1N1 2009 pandemic carried a variant form of the IFITM3 gene.

Aaron R. Everitt
Simon Clare
Paul Kellam
Research25 Mar 2012
Nature

Volume: 484, P: 519-523
A comparative analysis of rod bipolar cell transcriptomes identifies novel genes implicated in night vision

Sasha M. Woods
Edward Mountjoy
Denize Atan
ResearchOpen Access03 Apr 2018
Scientific Reports

Volume: 8, P: 1-15
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E23
Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
Amendments and CorrectionsOpen Access07 Jun 2022
Nature

Volume: 606, P: E18
Publisher Correction: Sensitivity and specificity of blood-fluid levels for oral anticoagulant-associated intracerebral haemorrhage

Abeer Almarzouki
Duncan Wilson
David J. Werring
Amendments and CorrectionsOpen Access28 Apr 2021
Scientific Reports

Volume: 11, P: 1
Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Brian J. Willett
Joe Grove
Emma C. Thomson
Amendments and CorrectionsOpen Access16 Sept 2022
Nature Microbiology

Volume: 7, P: 1709
AusTraits, a curated plant trait database for the Australian flora

Daniel Falster
Rachael Gallagher
Kasia Ziemińska
ResearchOpen Access30 Sept 2021
Scientific Data

Volume: 8, P: 1-20
Maximizing the potential of aggressive mouse tumor models in preclinical drug testing

M. Tarek Elghetany
Jia-Min Ho
Wan-Yee Teo
ResearchOpen Access02 Jun 2021
Scientific Reports

Volume: 11, P: 1-15

Search

A retrospective cohort study of valproate and infertility in men with epilepsy or bipolar disorder using international health data

Geological Climates

Shared heritability and functional enrichment across six solid cancers

Ecological adaptation drives wood frog population divergence in life history traits

Transcriptional activity and strain-specific history of mouse pseudogenes

Deep formation of Earth’s earliest continental crust consistent with subduction

Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

Rapid discharge connects Antarctic subglacial lakes

Impaired cell fate through gain-of-function mutations in a chromatin reader

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci

SARS-CoV-2 evolution during treatment of chronic infection

Sensitivity and specificity of blood-fluid levels for oral anticoagulant-associated intracerebral haemorrhage

SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Genomic reconstruction of the SARS-CoV-2 epidemic in England

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders

A systematic global stocktake of evidence on human adaptation to climate change

Crystallographic and geochemical responses of giant clams on turbid reefs

Publisher Correction: Shared heritability and functional enrichment across six solid cancers

Plasma Exosome Profiling of Cancer Patients by a Next Generation Systems Biology Approach

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study

IFITM3 restricts the morbidity and mortality associated with influenza

A comparative analysis of rod bipolar cell transcriptomes identifies novel genes implicated in night vision

Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Publisher Correction: Sensitivity and specificity of blood-fluid levels for oral anticoagulant-associated intracerebral haemorrhage

Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

AusTraits, a curated plant trait database for the Australian flora

Maximizing the potential of aggressive mouse tumor models in preclinical drug testing

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