Nature Search

Pervasive lesion segregation shapes cancer genome evolution

Mutagenic lesions such as those that give rise to cancer frequently segregate—unrepaired—during cell division, resulting in phasing of multiple alleles across generations of daughter cells and consequent tumour heterogeneity.

Sarah J. Aitken
Craig J. Anderson
Martin S. Taylor
Research24 Jun 2020
Nature

Volume: 583, P: 265-270
Strand-resolved mutagenicity of DNA damage and repair

How strand-asymmetric processes such as replication and transcription interact with DNA damage to drive mechanisms of repair and mutagenesis is explored.

Craig J. Anderson
Lana Talmane
Martin S. Taylor
ResearchOpen Access12 Jun 2024
Nature

Volume: 630, P: 744-751
Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution

“Variation in the noncoding regulatory sequences in the genome plays important roles in human disease and evolution. Here, the authors use F1 mouse hybrids to shed light on the regulatory mechanisms mediating transcription factor binding, chromatin state and gene expression in mammalian cells.”

Emily S. Wong
Bianca M. Schmitt
Paul Flicek
ResearchOpen Access23 Oct 2017
Nature Communications

Volume: 8, P: 1-13
Complexity and conservation of regulatory landscapes underlie evolutionary resilience of mammalian gene expression

Analysis of promoter and enhancer activity and levels of downstream transcripts in liver samples from 15 mammalian species finds an association between the complexity of the regulatory landscape and the evolutionary stability of gene expression.

Camille Berthelot
Diego Villar
Paul Flicek
Research27 Nov 2017
Nature Ecology & Evolution

Volume: 2, P: 152-163
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

New methods and larger sample groups are used to precisely determine the alleles in the HLA complex which contribute susceptibility to type 1 diabetes.

Sergey Nejentsev
Joanna M. M. Howson
Jane Worthington
Research14 Nov 2007
Nature

Volume: 450, P: 887-892
Coastal wetlands can be saved from sea level rise by recreating past tidal regimes

Mahmood Sadat-Noori
Caleb Rankin
William Glamore
ResearchOpen Access13 Jan 2021
Scientific Reports

Volume: 11, P: 1-10
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients

John D. Isaacs
Sarah Brockbank
Simon Read
ResearchOpen Access09 May 2022
Scientific Data

Volume: 9, P: 1-13
Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa

L M Huckins
K Hatzikotoulas
E Zeggini
ResearchOpen Access25 Jul 2017
Molecular Psychiatry

Volume: 23, P: 1169-1180

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Pervasive lesion segregation shapes cancer genome evolution

Strand-resolved mutagenicity of DNA damage and repair

Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution

Complexity and conservation of regulatory landscapes underlie evolutionary resilience of mammalian gene expression

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

Coastal wetlands can be saved from sea level rise by recreating past tidal regimes

RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients

Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa

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