Nature Search

Improved allele frequencies in gnomAD through local ancestry inference

This study incorporates local ancestry into the Genome Aggregation Database (gnomAD) to improve allele frequency estimates for admixed populations, enhancing variant interpretation and enabling more accurate and equitable genomic research and clinical care.

Pragati Kore
Michael W. Wilson
Elizabeth G. Atkinson
ResearchOpen Access06 Oct 2025
Nature Communications

Volume: 16, P: 1-10
Actomyosin-like Protein from Crayfish Nerve: a Possible Molecular Explanation of Permeability Changes during Excitation

K. BOWLER
C. J. DUNCAN
Research06 Aug 1966
Nature

Volume: 211, P: 642-643
A twenty-first century science

If handled appropriately, data about Internet-based communication and interactivity could revolutionize our understanding of collective human behaviour.

Duncan J. Watts
Comments & Opinion31 Jan 2007
Nature

Volume: 445, P: 489
Intermediates in the folding of the membrane protein bacteriorhodopsin

Paula J. Booth
Sabine L. Flitsch
H. Gobind Khorana
Research01 Feb 1995
Nature Structural Biology

Volume: 2, P: 139-143
Muscular Dystrophy of Beef Cattle and Unsaturated Fats

G. A. GARTON
W. R. H. DUNCAN
M. K. HUTCHESON
Research28 Apr 1956
Nature

Volume: 177, P: 792-793
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Continuous flow chemistry for molecular synthesis

Flow chemistry is a synthesis technique that uses pumps, tubing and connectors to control reactions spatially rather than temporally. This spatial control enables faster reaction times, better temperature regulation and higher yields over traditional batch processes, making it advantageous for the synthesis of pharmaceuticals, agrochemicals and advanced materials.

Sarah E. Raby-Buck
Jonathan Devlin
Duncan L. Browne
Reviews17 Jul 2025
Nature Reviews Methods Primers

Volume: 5, P: 1-19
Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2

The innate immune response in epithelial cells after SARS-CoV-2 infection is not fully understood. Here the authors use human air-liquid interface culture and show single cell transcription changes and delayed type I Interferon responses after SARS-CoV-2 infection compared with other respiratory viruses.

Catherine F. Hatton
Rachel A. Botting
Christopher J. A. Duncan
ResearchOpen Access07 Dec 2021
Nature Communications

Volume: 12, P: 1-17
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

Peter Sandercock
Janet Darbyshire
Martin J. Landray
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Should social science be more solution-oriented?

Duncan Watts considers whether many branches of social science could benefit from setting research goals aimed at specific and manageable real-world problems. He gives examples and discusses how more solution-oriented social science might work.

Duncan J. Watts
Reviews10 Jan 2017
Nature Human Behaviour

Volume: 1, P: 1-5
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia

Exome sequencing analysis of 13,933 individuals with bipolar disorder finds enrichment of ultra-rare protein-truncating variants in constrained genes. Combined analysis with schizophrenia exome data identifies AKAP11 as a risk gene for both disorders.

Duncan S. Palmer
Daniel P. Howrigan
Benjamin M. Neale
Research11 Apr 2022
Nature Genetics

Volume: 54, P: 541-547
Home of a fast radio burst

Our understanding of fast radio bursts — intense pulses of radio waves — and their use as cosmic probes promises to be transformed now that one burst has been associated with a galaxy of known distance from Earth. See Letter p.453

Duncan Lorimer
News & Views24 Feb 2016
Nature

Volume: 530, P: 427-428
Rare coding variants in ten genes confer substantial risk for schizophrenia

Whole-exome sequencing identifies ten risk genes for schizophrenia implicated by rare protein-coding variants, a subset of which overlap with risk genes in other neurodevelopmental disorders.

Tarjinder Singh
Timothy Poterba
Mark J. Daly
Research08 Apr 2022
Nature

Volume: 604, P: 509-516
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

Dinesh Aggarwal
Ben Warne
Ian G. Goodfellow
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-16
Resilient cooperators stabilize long-run cooperation in the finitely repeated Prisoner’s Dilemma

Studying the dynamics of learning in repeated games of cooperation is complicated by the short duration of traditional experiments. Here the authors perform a virtual prisoner's dilemma game over twenty consecutive days, finding that a minority of resilient co-operators can sustain cooperation indefinitely.

Andrew Mao
Lili Dworkin
Duncan J. Watts
ResearchOpen Access13 Jan 2017
Nature Communications

Volume: 8, P: 1-10
Collective dynamics of ‘small-world’ networks

Duncan J. Watts
Steven H. Strogatz
Research04 Jun 1998
Nature

Volume: 393, P: 440-442
The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses

Woong-Kyung Suh
Beata U Gajewska
Tak W Mak
Research17 Aug 2003
Nature Immunology

Volume: 4, P: 899-906
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
A research agenda for encouraging prosocial behaviour on social media

Dörr et al. argue that research on social media has mainly focused on antisocial behaviours and call for more research on the ways in which social media platforms can empower prosocial behaviour.

Timothy Dörr
Trisha Nagpal
Chris Bail
Reviews10 Mar 2025
Nature Human Behaviour

Volume: 9, P: 441-449
Evidence for light-by-light scattering in heavy-ion collisions with the ATLAS detector at the LHC

Quantum electrodynamics predicts a rare process in which light is scattered by light. The ATLAS Collaboration reports signs of this elusive effect in the collisions of ultra-relativistic lead ions.

M. Aaboud
G. Aad
L. Zwalinski
ResearchOpen Access14 Aug 2017
Nature Physics

Volume: 13, P: 852-858
Giving waste water the power to clean itself

A novel form of renewable energy can generate electricity from waste-water treatment.

Duncan Graham-Rowe
News01 Mar 2012
Nature
Observation of electroweak production of two jets and a Z-boson pair

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access09 Feb 2023
Nature Physics

Volume: 19, P: 237-253
The exciting potential and daunting challenge of using GPS human-mobility data for epidemic modeling

While large-scale GPS location datasets have been instrumental to applications in epidemiology, there are still several challenges with these data that should be considered and addressed to make data-driven epidemiology more reliable.

Francisco Barreras
Duncan J. Watts
Reviews19 Jun 2024
Nature Computational Science

Volume: 4, P: 398-411
An iron-catalysed C–C bond-forming spirocyclization cascade providing sustainable access to new 3D heterocyclic frameworks

The use of earth-abundant metals in catalysis is a prerequisite for the development of sustainable synthetic chemical processes for the future. Now, biomass-derived chemicals can be used in an efficient iron-catalysed reaction to make complex spirocycles. The resulting products contain two asymmetric centres that are furnished in high stereoselectivity.

Kirsty Adams
Anthony K. Ball
Joseph B. Sweeney
Research12 Dec 2016
Nature Chemistry

Volume: 9, P: 396-401
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
The evolution of cultural diversity in Pama-Nyungan Australia

Duncan Learmouth
Robert. H. Layton
Jamshid. J. Tehrani
ResearchOpen Access22 Jul 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-16
Predicting history

Risi et al. apply machine learning prediction models to nearly two million US Department of State cables from the 1970s to show that, although it is possible to develop ‘artificial archivists’, historical significance is extremely difficult to predict.

Joseph Risi
Amit Sharma
Duncan J. Watts
Research03 Jun 2019
Nature Human Behaviour

Volume: 3, P: 906-912
Unpacking media bias in the growing divide between cable and network news

Homa Hosseinmardi
Samuel Wolken
Duncan J. Watts
ResearchOpen Access21 May 2025
Scientific Reports

Volume: 15, P: 1-13
Integrating explanation and prediction in computational social science

The combination of computational and social sciences requires the integration of explanatory and predictive approaches into ‘integrative modelling’, according to Hofman and colleagues.

Jake M. Hofman
Duncan J. Watts
Tal Yarkoni
Reviews30 Jun 2021
Nature

Volume: 595, P: 181-188
Immunodetectable cyclin D₁is associated with oestrogen receptor but not Ki67 in normal, cancerous and precancerous breast lesions

B S Shoker
C Jarvis
J P Sloane
ResearchOpen Access17 Apr 2001
British Journal of Cancer

Volume: 84, P: 1064-1069
Averting biodiversity collapse in tropical forest protected areas

Analysis of changes in functional groups of species and potential drivers of environmental change for protected areas across the world’s major tropical regions reveals large variation between reserves that have been effective and those experiencing an erosion of biodiversity, and shows that environmental changes immediately outside reserves are nearly as important as those inside in determining their ecological fate.

William F. Laurance
D. Carolina Useche
Franky Zamzani
Research25 Jul 2012
Nature

Volume: 489, P: 290-294
Misunderstanding the harms of online misinformation

This Perspective identifies common misperceptions regarding the harms of online misinformation, finding that exposure to false and inflammatory content is rare and concentrated among a small minority of people who already have extreme views.

Ceren Budak
Brendan Nyhan
Duncan J. Watts
Reviews05 Jun 2024
Nature

Volume: 630, P: 45-53
Redefine statistical significance

We propose to change the default P-value threshold for statistical significance from 0.05 to 0.005 for claims of new discoveries.

Daniel J. Benjamin
James O. Berger
Valen E. Johnson
Comments & Opinion01 Sept 2017
Nature Human Behaviour

Volume: 2, P: 6-10
Graph neural network-based cell switching for energy optimization in ultra-dense heterogeneous networks

Kang Tan
Duncan Bremner
Muhammad Ali Imran
ResearchOpen Access14 Dec 2022
Scientific Reports

Volume: 12, P: 1-18
Continuous borehole optical televiewing reveals variable englacial debris concentrations at Khumbu Glacier, Nepal

High vertical variation in englacial debris concentration is found in four 150 m-deep borehole optical televiewer logs in Khumbu Glacier, Nepal, with vertically averaged englacial debris concentrations of up to 6.4% by volume towards the terminus.

Katie E. Miles
Bryn Hubbard
Josephine Hornsey
ResearchOpen Access13 Jan 2021
Communications Earth & Environment

Volume: 2, P: 1-9
NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health

This Perspective lays out the impetus and goals of the Cellular Senescence Network established to comprehensively identify and characterize senescent cells (SnCs) across tissues and lifespan, providing a publicly available SnC atlas.

Patty J. Lee
Christopher C. Benz
Mingyu Yang
Reviews20 Dec 2022
Nature Aging

Volume: 2, P: 1090-1100
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E23
Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards

Maja Kopczynska
Harry Unwin
Judith E. Hall
ResearchOpen Access10 Aug 2021
Scientific Reports

Volume: 11, P: 1-12

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