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Showing 1–9 of 9 results
Advanced filters: Author: Dunja Aksentijevic Clear advanced filters

  • The naked mole-rat exhibits extreme longevity, resistance to hypoxia and absence of cardiovascular disease. Here, Faulkes et al. identify mechanisms behind these traits by comparing cardiac metabolomes and transcriptomes of naked more-rats to other African mole-rat genera and evolutionary divergent mammals.

    • Chris G. Faulkes
    • Thomas R. Eykyn
    • Dunja Aksentijevic
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • In this Review, the authors focus on the tight interaction between cardiac mechanics and mitochondrial energetics, discuss how this mechano-energetic coupling is disturbed in various acquired and inherited forms of heart failure, and summarize the established and emerging treatments for heart failure that target this mechano-energetic uncoupling.

    • Dunja Aksentijevic
    • Simon Sedej
    • Christoph Maack
    Reviews
    Nature Reviews Cardiology
    Volume: 22, P: 773-797

  • Reactive oxygen species (ROS) production by reverse electron transfer (RET) through complex I is thought to cause tissue damage from heart attacks. Here, the authors combine in vivo work with biochemical and cryo-EM analyses to characterize the effects of a P25L mutation in the ND6 subunit of mitochondrial complex I. They observe that this mutation does not affect oxidative phosphorylation but renders complex I unable to generate ROS by RET: ND6-P25L mice are protected against cardiac ischaemia–reperfusion injury, thus providing evidence for the proposed role of ROS production in myocardial infarction.

    • Zhan Yin
    • Nils Burger
    • Judy Hirst
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • The failing heart is characterised by both alterations in mitochondrial metabolism and an elevation of cytosolic sodium. Here, the authors use 23Na NMR and metabolic profiling to show these are related, and that elevation in intracellular Na reprograms cardiac substrate utilisation via effects on mitochondrial Na/Ca exchange.

    • Dunja Aksentijević
    • Anja Karlstaedt
    • Michael J. Shattock
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • The mechanisms that restore endothelial barrier integrity following inflammation-induced breaching are incompletely understood. Here the authors show that the CD31 immune receptor contributes to reestablishing vascular integrity via its effects on endothelial cell metabolism.

    • Kenneth C. P. Cheung
    • Silvia Fanti
    • Federica M. Marelli-Berg
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18

  • Chronic kidney disease is associated with an increased risk of cardiovascular disease, such as heart failure. Here, the authors examine myocardial metabolic remodelling in chronic kidney disease, including changes in energy substrate use, mitochondrial dysfunction and the role of cardiotonic steroids, and discuss potential metabolic therapies.

    • Nikayla Patel
    • Muhammad Magdi Yaqoob
    • Dunja Aksentijevic
    Reviews
    Nature Reviews Nephrology
    Volume: 18, P: 524-537

  • A metabolomics study on the ischaemic heart identifies succinate as a metabolite that drives the production of reactive oxygen species and contributes to ischaemia-reperfusion injury; pharmacological inhibition of succinate accumulation ameliorates ischaemia-reperfusion injury in a mouse model of heart attack and a rat model of stroke.

    • Edward T. Chouchani
    • Victoria R. Pell
    • Michael P. Murphy
    Research
    Nature
    Volume: 515, P: 431-435