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Advanced filters: Author: Dunja Petrovic Clear advanced filters

The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation

Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of pathological protein aggregation, highlighting EPS8 and its regulators as potential therapeutic targets.

Seda Koyuncu
Yaiza Dominguez-Canterla
David Vilchez
ResearchOpen Access03 Sept 2025
Nature Aging

Volume: 5, P: 1750-1770
ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1

The authors showed that, in C. elegans, inhibition of translation or mTORC1 increases ATF-4 expression independently of ISR signalling. ATF-4 promotes longevity by increasing hydrogen sulfide production by the enzyme CTH-2.

Cyril Statzer
Jin Meng
Collin Y. Ewald
ResearchOpen Access18 Feb 2022
Nature Communications

Volume: 13, P: 1-15
Reactivation of corticogenesis-related transcriptional factors BCL11B and SATB2 after ischemic lesion of the adult mouse brain

Sanja Srakočić
Dunja Gorup
Srećko Gajović
ResearchOpen Access26 May 2023
Scientific Reports

Volume: 13, P: 1-18

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