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Showing 1–2 of 2 results
Advanced filters: Author: Duoyi Zhao Clear advanced filters

  • In osteoporosis, bone marrow adipocytes (BMAds) accumulate, but their functions are not well understood. Here, Lin et al. show that BMAds promote senescence in neighbouring cells by releasing excess fatty acids, then develop a BMAd targeting nanoparticle to interfere with BMAd lipid metabolism as a strategy to treat osteoporosis.

    • Wenzheng Lin
    • Suyu Gu
    • Hao Chen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • LepR+ cells senescence is a driver of aging-induced bone marrow homeostasis collapse. Here, Li et al. report a LepR+ cell-targeting nitric oxide (NO) nanopump for rejuvenation of senescent LepR+ cells via activation of glycolysis signaling to reestablish homeostasis of the aged bone marrow.

    • Ke Li
    • Sihan Hu
    • Hao Chen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16