Actin condenses at the lamellipodium of migrating cells to form arc-like bundles parallel to the leading edge. During the retraction phase of the edge movement, these arcs are shown to be displaced towards the rear of the lamella, and their movement slows down when they join focal adhesions. Actin arcs thus provide a spatiotemporal connection between the lamellipodium and the lamella.
- Dylan T. Burnette
- Suliana Manley
- Jennifer Lippincott-Schwartz
