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Nature Cell Biology (1)

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Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis

Kumari et al. show that host-derived extracellular vesicles capture systemic LPS and transfer it to the cytosol of immune cells via CD14-dependent endocytosis, triggering caspase-11-mediated gasdermin D activation and pyroptosis.

Puja Kumari
Swathy O. Vasudevan
Vijay A. Rathinam
Research16 Nov 2023
Nature Cell Biology

Volume: 25, P: 1860-1872

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Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis

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