Nature Search

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Jose Florez, Claudia Langenberg, Erik Ingelsson, Inga Prokopenko, Inês Barroso and colleagues perform large-scale association analyses using the Metabochip to gain further insights into the genetic architecture of glucose regulation. They identify 38 new loci influencing 1 or more glycemic traits and show that many of these loci also modify risk of type 2 diabetes.

Robert A Scott
Vasiliki Lagou
Inês Barroso
Research12 Aug 2012
Nature Genetics

Volume: 44, P: 991-1005
Quantitative assessment of blood flow, blood volume and blood oxygenation effects in functional magnetic resonance imaging

Peter C.M. van Zijl
Scott M. Eleff
Risto A. Kauppinen
Research01 Feb 1998
Nature Medicine

Volume: 4, P: 159-167
Mapping 123 million neonatal, infant and child deaths between 2000 and 2017

A high-resolution, global atlas of mortality of children under five years of age between 2000 and 2017 highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.

Roy Burstein
Nathaniel J. Henry
Simon I. Hay
ResearchOpen Access16 Oct 2019
Nature

Volume: 574, P: 353-358
1234 Language Assessment of Nonhandicapped Twins

K Gucuyener
E Arhan
Y Atalay
Research01 Nov 2010
Pediatric Research

Volume: 68, P: 611
1233 Neonatal Outcomes of Large-Forgestational Age Infants Delivered by Women with and without Gestational Diabetes Mellitus?

E Onal
I M Hirfanoglu
Y Atalay
Research01 Nov 2010
Pediatric Research

Volume: 68, P: 611
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
ResearchOpen Access20 Apr 2020
Nature Medicine

Volume: 26, P: 750-759
Mapping routine measles vaccination in low- and middle-income countries

Although progress in the coverage of routine measles vaccination in children in low- and middle-income countries was made during 2000–2019, many countries remain far from the goal of 80% coverage in all districts by 2019.

Alyssa N. Sbarra
Sam Rolfe
Jonathan F. Mosser
ResearchOpen Access16 Dec 2020
Nature

Volume: 589, P: 415-419
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

An expanded GWAS of birth weight and subsequent analysis using structural equation modeling and Mendelian randomization decomposes maternal and fetal genetic contributions and causal links between birth weight, blood pressure and glycemic traits.

Nicole M. Warrington
Robin N. Beaumont
Rachel M. Freathy
Research01 May 2019
Nature Genetics

Volume: 51, P: 804-814
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Erik Ingelsson and colleagues report a large-scale genome-wide meta-analysis for associations to the extremes of anthropometric traits, including body mass index, height, waist-to-hip ratio and clinical obesity. They identify four loci newly associated with height and seven loci newly associated with clinical obesity and find overlap in the genetic structure and distribution of variants identified for these extremes of the trait distributions and for the general population.

Sonja I Berndt
Stefan Gustafsson
Erik Ingelsson
Research07 Apr 2013
Nature Genetics

Volume: 45, P: 501-512
Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth

Genome-wide analyses using fetal and parental genotypes identify 40 independent associations influencing placental weight and highlight the role of the fetus in preeclampsia risk and placental growth regulation via insulin signaling.

Robin N. Beaumont
Christopher Flatley
Pål R. Njølstad
ResearchOpen Access05 Oct 2023
Nature Genetics

Volume: 55, P: 1807-1819
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Claudia Langenberg, James Meigs and colleagues apply a joint meta-analysis approach that accounts for differences in body mass index to identify variants associated with glycemic traits. They report six new loci associated with fasting insulin levels and provide insights into the genetic basis of insulin resistance.

Alisa K Manning
Marie-France Hivert
Claudia Langenberg
Research13 May 2012
Nature Genetics

Volume: 44, P: 659-669
223 URINARY ENOOTHELIN-1 EXCRETION IN FUROSEMIDE-TREATED HUMAN NEONATES

E Sulyok
K Adamovich
W Rascher
Research01 Jul 1994
Pediatric Research

Volume: 36, P: 40
Extreme mitochondrial reduction in a novel group of free-living metamonads

Mitochondria are essential cellular components that are found in animals, plants, fungi, and protists. This study reports what is believed to be the first example of complete mitochondrial loss in a free-living organism, providing insights into the evolutionary plasticity of eukaryotic cells.

Shelby K. Williams
Jon Jerlström Hultqvist
Andrew J. Roger
ResearchOpen Access09 Aug 2024
Nature Communications

Volume: 15, P: 1-14
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Andrew Morris, Mark McCarthy, Michael Boehnke and colleagues report a meta-analysis of genome-wide association studies for type 2 diabetes, including 26,488 cases and 83,964 controls from populations of European, east Asian, south Asian and Mexican and Mexican American ancestry. They identify seven loci newly associated with type 2 diabetes and examine the genetic architecture of disease across populations.

Anubha Mahajan
Min Jin Go
Andrew P Morris
Research09 Feb 2014
Nature Genetics

Volume: 46, P: 234-244
Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

Chiea Chuen Khor, Tin Aung, Francesca Pasutto, Janey Wiggs and colleagues report a global genome-wide association study of exfoliation syndrome and a fine-mapping analysis of a previously identified disease-associated locus, LOXL1. They identify a rare protective variant in LOXL1 exclusive to the Japanese population and five new common variant susceptibility loci.

Tin Aung
Mineo Ozaki
Chiea Chuen Khor
Research29 May 2017
Nature Genetics

Volume: 49, P: 993-1004
Retinoblastoma outcomes in Europe: a prospective analysis of 483 patients from 40 countries

Richard Bowman
Mattan Arazi
Richard Bowman
Research17 Dec 2025
Eye

Volume: 40, P: 390-398
Pupillary responses to light are not affected by narrow irido-corneal angles

A. V. Rukmini
Raymond P. Najjar
Dan Milea
ResearchOpen Access31 Aug 2017
Scientific Reports

Volume: 7, P: 1-8
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Mark McCarthy, Michael Boehnke, Andrew Morris and colleagues perform large-scale association analyses using the Metabochip to gain insights into the genetic architecture of type 2 diabetes. They report several new susceptibility loci, including two that show sex-differentiated effects on disease risk.

Andrew P Morris
Benjamin F Voight
Mark I McCarthy
Research12 Aug 2012
Nature Genetics

Volume: 44, P: 981-990
101 Think Twice Before you Start Inotropic Treatment for Circulatory Support…are we Doing Good or Bad?

I M Hirfanoglu
E Ergenekon
Y Atalay
Research01 Nov 2010
Pediatric Research

Volume: 68, P: 54
1235 Follow-Up for Neurologic Disabilities in Very Low Weight Newborn Children Attended in Third Care Level Unit

E C Urbina
M F Castro
J C S Herrera
Research01 Nov 2010
Pediatric Research

Volume: 68, P: 611-612
Atrial fibrillation designation with micro-Raman spectroscopy and scanning acoustic microscope

Ugur Parlatan
Seyma Parlatan
Bukem Tanoren
ResearchOpen Access19 Apr 2022
Scientific Reports

Volume: 12, P: 1-9
Intermittent hypoxia inhibits epinephrine-induced transcriptional changes in human aortic endothelial cells

Rengul Cetin-Atalay
Angelo Y. Meliton
Gökhan M. Mutlu
ResearchOpen Access13 Oct 2022
Scientific Reports

Volume: 12, P: 1-13
Genome-wide associations for birth weight and correlations with adult disease

Multi-ancestry genome-wide association analyses for birth weight in 153,781 individuals identified 60 genomic loci in which birth weight and fetal genotype were associated and found an inverse genetic correlation between birth weight and cardiometabolic risk.

Momoko Horikoshi
Robin N. Beaumont
Rachel M. Freathy
Research28 Sept 2016
Nature

Volume: 538, P: 248-252
Vision-language model for report generation and outcome prediction in CT pulmonary angiogram

Zhusi Zhong
Yuli Wang
Harrison Bai
ResearchOpen Access12 Jul 2025
npj Digital Medicine

Volume: 8, P: 1-15
Genetic evidence of assortative mating in humans

Using whole-genome data for single-nucleotide polymorphism and results from genome-wide association studies, the authors show that people’s preference for pairing with those with similar phenotypic traits has genetic causes and consequences.

Matthew R. Robinson
Aaron Kleinman
Peter M. Visscher
Research09 Jan 2017
Nature Human Behaviour

Volume: 1, P: 1-13
Erratum: Common variants at 12q15 and 12q24 are associated with infant head circumference

H Rob Taal
Beate St Pourcain
James F Wilson
Amendments and Corrections29 May 2013
Nature Genetics

Volume: 45, P: 713
Erratum: Common variants at 6q22 and 17q21 are associated with intracranial volume

M Arfan Ikram
Myriam Fornage
James F Wilson
Amendments and Corrections29 May 2013
Nature Genetics

Volume: 45, P: 713
Common variants at 12q15 and 12q24 are associated with infant head circumference

Vincent Jaddoe and colleagues report a genome-wide association study for infant head circumference. They identify variants in SBNO1 and near HMGA2 that are associated with this phenotype.

H Rob Taal
Beate St Pourcain
James F Wilson
Research15 Apr 2012
Nature Genetics

Volume: 44, P: 532-538
Genetic origin of Behçet’s disease population in Denizli, Turkey; population genetics data analysis; historical demography and geographical perspectives based on β-globin gene cluster haplotype variation

O Ozturk
S Arikan
E O Atalay
Research29 Dec 2016
Genes & Immunity

Volume: 18, P: 28-32
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

A Hinney
M Kesselmeier
J Hebebrand
Research17 May 2016
Molecular Psychiatry

Volume: 22, P: 192-201
Schedule-dependent activity of 5-fluorouracil and irinotecan combination in the treatment of human colorectal cancer: in vitro evidence and a phase I dose-escalating clinical trial

C Barone
M Landriscina
A Cassano
ResearchOpen Access12 Dec 2006
British Journal of Cancer

Volume: 96, P: 21-28
Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
Amendments and CorrectionsOpen Access02 Jul 2020
Nature Medicine

Volume: 26, P: 1308
Quantitative imaging of tumour blood flow by contrast-enhanced magnetic resonance imaging

S Pahernik
J Griebel
A E Goetz
ResearchOpen Access27 Nov 2001
British Journal of Cancer

Volume: 85, P: 1655-1663
Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin

Ellen H. J. van den Bogaard
Michel van Geel
Patrick L. J. M. Zeeuwen
ResearchOpen Access14 Nov 2018
Genetics in Medicine

Volume: 21, P: 1559-1567
Common variants at 6q22 and 17q21 are associated with intracranial volume

M. Arfan Ikram and colleagues report a genome-wide association study for intracranial volume and brain volume. They report two loci associated with intracranial volume.

M Arfan Ikram
Myriam Fornage
James F Wilson
Research15 Apr 2012
Nature Genetics

Volume: 44, P: 539-544
Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children

T M Schnurr
A Viitasalo
T Hansen
Research26 Sept 2017
International Journal of Obesity

Volume: 42, P: 111-114
Association of MBOAT7 gene variant with plasma ALT levels in children: the PANIC study

Anna Viitasalo
Aino-Maija Eloranta
Timo A. Lakka
Research13 Jul 2016
Pediatric Research

Volume: 80, P: 651-655
Genetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents

Anna Viitasalo
Theresia M. Schnurr
Tuomas O. Kilpeläinen
ResearchOpen Access22 Jul 2019
International Journal of Obesity

Volume: 43, P: 2007-2016
Measuring changes in human tumour vasculature in response to therapy using functional imaging techniques

H Anderson
P Price
P Workman
EditorialOpen Access16 Oct 2001
British Journal of Cancer

Volume: 85, P: 1085-1093
A prelude to the proximity interaction mapping of CXXC5

Gamze Ayaz
Gizem Turan
Pelin Yaşar
ResearchOpen Access02 Sept 2021
Scientific Reports

Volume: 11, P: 1-19
Maternal and fetal genetic contribution to gestational weight gain

N M Warrington
R Richmond
D A Lawlor
ResearchOpen Access09 Oct 2017
International Journal of Obesity

Volume: 42, P: 775-784

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