The function of oxidation of specific proteins during apoptosis has been unclear. Oxidation of the actin-binding protein cofilin induces its translocation to the mitochondria, where it triggers the opening of the permeability transition pore independently of the BH3-only apoptotic factor Bax, and is required for oxidant-induced apoptosis.
- Fábio Klamt
- Stéphanie Zdanov
- Emily Shacter
