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Showing 1–13 of 13 results
Advanced filters: Author: E Tsochatzis Clear advanced filters

  • Although nonalcoholic fatty liver disease is the most prevalent liver disease worldwide, there is a paucity of good-quality data on its natural history and most studies to date have reported on retrospective data. Robust data are required to inform regulatory end points, trial design and models of care.

    • Emmanuel A. Tsochatzis
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 19, P: 151-152

  • Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease with a substantial burden worldwide. In this Consensus Statement, a global multidisciplinary group of experts develop consensus statements and recommendations addressing a broad range of topics on NAFLD to raise awareness and spur action.

    • Jeffrey V. Lazarus
    • Henry E. Mark
    • Ming-Hua Zheng
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 19, P: 60-78

  • Reducing the stigma and discrimination that people living with liver conditions experience requires rethinking how diagnoses, diseases, etiologies and circumstances are perceived — a shift that begins with the language used to name and describe them.

    • Jeffrey V. Lazarus
    • Dana Ivancovsky Wajcman
    • Marcela Villota-Rivas
    Comments & Opinion
    Nature Medicine
    Volume: 31, P: 2109-2116

  • The practical rules for the early non-invasive diagnosis of cirrhosis in NAFLD are not well defined. Here, the authors develop and validate two diagnostic tools: a stepwise stratification algorithm including a cirrhosis group, and a risk prediction chart providing a personalized assessment of the individual probability of cirrhosis.

    • Jérôme Boursier
    • Marine Roux
    • Philip N. Newsome
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Endoscopic band ligation (EBL) and nonselective β-blockade are two effective strategies in the primary prevention of variceal bleeding. Meta-analyses have shown an advantage of EBL over propranolol with regard to bleeding rates but not mortality. By contrast, a recent randomized, controlled trial shows less bleeding associated with the use of carvedilol compared with EBL.

    • Emmanuel A. Tsochatzis
    • Christos K. Triantos
    • Andrew K. Burroughs
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 6, P: 692-694

  • Metabolic dysfunction-associated steatohepatitis (MASH), a primary cause of chronic liver disease (CLD), often leads to advanced CLD stages such as cirrhosis. This Roadmap summarizes the current landscape and challenges of MASH-related compensated cirrhosis clinical trials and explores a way forward for future studies.

    • Juan M. Pericàs
    • Quentin M. Anstee
    • Joan Genescà
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 21, P: 809-823

  • This Review describes the progression of advanced chronic liver disease (ACLD) from its early stages (compensated ACLD) to more advanced disease (decompensated ACLD). Evidence supporting strategies to manage ACLD and prevent decompensation, as well as the tests used to stratify risk, are discussed.

    • Càndid Villanueva
    • Dhiraj Tripathi
    • Jaume Bosch
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 22, P: 265-280

  • This Consensus Statement discusses the relationship between hyperferritinaemia and iron accumulation in individuals with metabolic dysfunction. The authors propose an updated definition and a provisional staging system for metabolic hyperferritinaemia, highlight research gaps and provide suggestions for the design and outcome measures for future studies.

    • Luca Valenti
    • Elena Corradini
    • Heinz Zoller
    Reviews
    Nature Reviews Endocrinology
    Volume: 19, P: 299-310

  • There is a need for effective models of care for patients with non-alcoholic fatty liver disease (NAFLD). In this Expert Recommendation, Lazarus et al. discuss seven examples of comprehensive NAFLD models of care and produce eight recommendations aimed at policy-makers and practitioners.

    • Jeffrey V. Lazarus
    • Quentin M. Anstee
    • Jörn M. Schattenberg
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 18, P: 717-729