With age, muscle stem cells have been reported to undergo a quiescence-to-senescence switch, thus reducing regenerative capacity. Here, using in vitro and mouse models, Guerrero et al. report that treatment with 3-deazaadenosine alleviates senescence and preserves the regenerative potential of muscle and hematopoietic stem cells.
- Ana Guerrero
- Andrew J. Innes
- Jesús Gil
