Glycosphingolipid modulation may be a new approach to treat polycystic kidney disease. Blocking glucosylceramide accumulation with a glucosylceramide synthase inhibitor inhibits cyst formation in mouse models of the disease through inhibition of Akt-mediated signaling and by interfering with the cell cycle machinery.
- Thomas A Natoli
- Laurie A Smith
- Oxana Ibraghimov-Beskrovnaya
