EPEC and EHEC encode both the ligand and receptor required to trigger actin-pedestal assembly in intestinal epithelial cells. Here, the authors discuss the latest data on this interaction and how this system can be used to model eukaryotic transmembrane receptor signalling processes, including immunological synapse and focal-adhesion formation.
- Richard D. Hayward
- John M. Leong
- Kenneth G. Campellone