This paper describes the use of optical microendoscopy to visualize sarcomeres and their micron-scale motions in live mice and humans, revealing unanticipated local variations in sarcomere lengths. Imaging of human sarcomeres is expected to enable advances in biomechanical modelling, orthopedic therapeutics, and the understanding and treatment of neuromuscular disorders
- Michael E. Llewellyn
- Robert P. J. Barretto
- Mark J. Schnitzer