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Showing 1–6 of 6 results
Advanced filters: Author: E. Michael Ostap Clear advanced filters

  • Omecamtiv mecarbil (OM) is a positive cardiac inotrope in clinical trials for the treatment of heart failure whose mechanism of action is incompletely understood. Here the authors show that OM inhibits myosin's working stroke and prolongs actomyosin attachment and propose a model that reconciles the OM-induced increase in cardiac performance in vivo with the inhibitory actions observed in vitro.

    • Michael S. Woody
    • Michael J. Greenberg
    • E. Michael Ostap
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • A mitochondrial actin wave fragments mitochondria. Here, the authors find that the wave produces force that is resisted by mitochondrial tethering, inducing fission, with subsequent fusion promoting mitochondrial content mixing and mitochondrial homeostasis.

    • Stephen M. Coscia
    • Andrew S. Moore
    • Erika L. F. Holzbaur
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • It remains unclear how the dynactin complex activates cytoplasmic dynein motor proteins. Ayloo et al.use single molecule imaging to observe dynein–dynactin behaviour on microtubules, and show that dynactin recruits dynein to microtubules and acts as a brake to slow the motor.

    • Swathi Ayloo
    • Jacob E. Lazarus
    • Erika L. F. Holzbaur
    Research
    Nature Communications
    Volume: 5, P: 1-11

  • CARMIL regulates actin capping proteins at the leading edge of migrating cells. By solving the crystal structure of the CARMIL N-terminal region, Zwolak et al. discover that this region encodes a cryptic pleckstrin homology domain, and show that it mediates association with the plasma membrane.

    • Adam Zwolak
    • Changsong Yang
    • Roberto Dominguez
    Research
    Nature Communications
    Volume: 4, P: 1-10