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Showing 1–16 of 16 results
Advanced filters: Author: EDWARD L. LICHTENSTEIN Clear advanced filters

  • A genetic study identifies hundreds of loci associated with risk tolerance and risky behaviors, finds evidence of substantial shared genetic influences across these phenotypes, and implicates genes involved in neurotransmission.

    • Richard Karlsson Linnér
    • Pietro Biroli
    • Jonathan P. Beauchamp
    Research
    Nature Genetics
    Volume: 51, P: 245-257

  • Small molecule metabolites like phenylalanine can form amyloid-like structures but so far this has only been demonstrated in vitro. Here the authors generate a yeast in vivo model of adenine self-assembly and characterize the adenine assemblies in cells by indicative amyloid dye and anti-adenine assemblies antibodies.

    • Dana Laor
    • Dorin Sade
    • Ehud Gazit
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • A massive field study whereby many different treatments are tested synchronously in one large sample using a common objectively measured outcome, termed a megastudy, was performed to examine the ability of interventions to increase gym attendance by American adults.

    • Katherine L. Milkman
    • Dena Gromet
    • Angela L. Duckworth
    Research
    Nature
    Volume: 600, P: 478-483

  • Better analytical methods are needed to extract biological meaning from genome-wide association studies (GWAS) of psychiatric disorders. Here the authors take GWAS data from over 60,000 subjects, including patients with schizophrenia, bipolar disorder and major depression, and identify common etiological pathways shared amongst them.

    • Colm O'Dushlaine
    • Lizzy Rossin
    • Gerome Breen
    Research
    Nature Neuroscience
    Volume: 18, P: 199-209

  • An integrated transcriptome, genome, methylome and proteome analysis of over 200 lung adenocarcinomas reveals high rates of somatic mutations, 18 statistically significantly mutated genes including RIT1 and MGA, splicing changes, and alterations in MAPK and PI(3)K pathway activity.

    • Eric A. Collisson
    • Joshua D. Campbell
    • Ming-Sound Tsao
    ResearchOpen Access
    Nature
    Volume: 511, P: 543-550

  • The genetics of schizophrenia and other mental disorders are complex and poorly understood, and made even harder to study due to reduced reproduction resulting in negative selection pressure on risk alleles. Two independent large-scale genome wide studies of thousands of patients and controls by two international consortia confirm a previously identified locus, but also reveal novel associations. In this study, deletions were reported on chromosomes 1 and 15, as well as a greater overall frequency of copy number variation in the genome.

    • Jennifer L. Stone
    • Michael C. O’Donovan
    • Pamela Sklar
    Research
    Nature
    Volume: 455, P: 237-241

  • Naomi Wray and colleagues report an analysis of genome-wide association data sets from the Psychiatric Genomics Consortium for five psychiatric disorders. They find that common variation explains 17–29% of the variance in liability and provide further support for a shared genetic etiology for these related psychiatric disorders.

    • S Hong Lee
    • Stephan Ripke
    • Naomi R Wray
    Research
    Nature Genetics
    Volume: 45, P: 984-994

  • In the second of three papers on the genetics of schizophrenia, a large genome-wide association study looking at common genetic variants underlying the risk of schizophrenia implicates the major histocompatibility complex — and thus, immunity — and provides molecular genetic evidence for a substantial polygenic component to the risk of schizophrenia. The latter involves thousands of common alleles of very small effect that also contribute to the risk of bipolar disorder.

    • Shaun M. Purcell
    • Naomi R. Wray
    • Pamela Sklar
    Research
    Nature
    Volume: 460, P: 748-752

  • The Psychiatric GWAS Consortium Bipolar Disorder Working Group reports a large-scale genome-wide association study of 7,481 individuals with bipolar disorder with replication in 4,493 cases. The Consortium identifies a new susceptibility locus near ODZ4 and replicates a known association near CACNA1C for bipolar disorder.

    • Pamela Sklar
    • Stephan Ripke
    • Shaun M Purcell
    Research
    Nature Genetics
    Volume: 43, P: 977-983

  • The Schizophrenia Psychiatric Genome-Wide Association Study Consortium reports five genetic loci newly associated with risk of schizophrenia, involving 17,836 cases of schizophrenia and 33,859 healthy controls. The new locus with the strongest support of association was located within an intron for microRNA 137, a known regulator of neuronal development. Four other genome-wide significant loci for schizophrenia contain predicted targets of MIR137, suggesting that disruption to pathways involving MIR137 may be an etiologic mechanism in schizophrenia.

    • Stephan Ripke
    • Alan R Sanders
    • Pablo V Gejman
    Research
    Nature Genetics
    Volume: 43, P: 969-976

  • Simone de Jong et al. examine the balance of common and rare risk for psychiatric disorders in a large family with high incidence of Bipolar Disorder and Major Depressive Disorder. They find that increased polygenic risk over generations could be partially due to assortative mating, which may explain the observation of anticipation in mood disorders.

    • Simone de Jong
    • Mateus Jose Abdalla Diniz
    • Gerome Breen
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-10