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Individualized prevention of proton pump inhibitor related adverse events by risk stratification

The safety profile of proton pump inhibitor (PPI) use remains controversial. Here, the authors show that PPI use is associated with an increased risk of 15 leading global diseases, with absolute risks increasing with baseline risks, highlighting the need for personalized PPI use strategies.

Bin Xia
Qiangsheng He
Jinqiu Yuan
ResearchOpen Access27 Apr 2024
Nature Communications

Volume: 15, P: 1-12
NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance

Lactylation of NBS1 by TIP60 promotes homologous recombination-driven DNA repair and resistance to chemotherapy in cancer cells and links altered cancer cell metabolism to increase genome stability.

Hengxing Chen
Yun Li
Changhua Zhang
ResearchOpen Access03 Jul 2024
Nature

Volume: 631, P: 663-669
The network structure of self-compassion in older adults with different productive engagement patterns

Huinan Hu
Grand H.-L. Cheng
H. N. Cheung
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-13