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Showing 1–3 of 3 results
Advanced filters: Author: Edgar A Ycu Clear advanced filters

  • The strength of aversive learning is proportional to the intensity of aversive experiences, but how brain circuits set memory strength during learning is not known. The authors show that an amygdala-to-midbrain feedback circuit conveying information about future unpleasant experiences inhibits aversive processing during learning to calibrate memory strength.

    • Takaaki Ozawa
    • Edgar A Ycu
    • Joshua P Johansen
    Research
    Nature Neuroscience
    Volume: 20, P: 90-97

  • Learning which environmental cues predict harm is paramount to survival, yet evidence for these associations is often ambiguous. The authors demonstrate a critical role for the amygdala in evaluating such ambiguities and show that a computational framework based on structure learning can explain this process.

    • Tamas J Madarasz
    • Lorenzo Diaz-Mataix
    • Joshua P Johansen
    Research
    Nature Neuroscience
    Volume: 19, P: 965-972

  • A small population of brainstem noradrenaline neurons powerfully modulates global brain function, but how they regulate diverse—and at times opposing—functions is not clear. The authors report that a modular organization in this neuromodulatory system, coupled with context-dependent activation modes, controls the balance between opposing emotional and flexible learning states.

    • Akira Uematsu
    • Bao Zhen Tan
    • Joshua P Johansen
    Research
    Nature Neuroscience
    Volume: 20, P: 1602-1611