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Showing 1–5 of 5 results
Advanced filters: Author: Edna Matta-Camacho Clear advanced filters

  • Ubr1 and Ubr2 are E3 ligases that target substrates by the N-end rule, and it is the UBR box that is needed for substrate recognition. The structures of the UBR boxes of human UBR1 and UBR2 show that they adopt a previously undescribed fold stabilized by zinc. One of the zinc-binding ligands is mutated in Johnson-Blizzard syndrome and leads to UBR box unfolding.

    • Edna Matta-Camacho
    • Guennadi Kozlov
    • Kalle Gehring
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 1182-1187

  • Some nuclear receptors dimerize with retinoid X receptor to allow ligand-dependent signalling. Here, Kojetin et al.use structural and biophysical techniques to identify structural changes that guide these complex signalling networks.

    • Douglas J. Kojetin
    • Edna Matta-Camacho
    • Kendall W. Nettles
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-14

  • Although issues surrounding diversity and inclusion in science are global, distinctive region-specific socioeconomic factors and operational biases interact to widen the opportunity gap and exacerbate the isolation of specific groups of disadvantaged scientists on the global stage. This commentary reviews the issues currently faced by the Latin American (neuro)science community and outlines key actions on multiple fronts to overcome the barriers impeding their global inclusion, visibility and success.

    • Ana Silva
    • Keerthana Iyer
    • Carmen Sandi
    Comments & Opinion
    Nature Neuroscience
    Volume: 25, P: 1115-1118

  • Translation of mRNA contributes to neuronal function and complex behaviours, and inflammation is thought to contribute to depression. Here the authors show that mice lacking phosphorylation sites in eIF4E (eukaryotic initiation factor 4E) display anxiety- and depression-like behaviour and decreased IkBα expression; furthermore TNFα delivery to the medial prefrontal cortex induces depression-like behaviour and deficits in serotonergic transmission.

    • Argel Aguilar-Valles
    • Nabila Haji
    • Nahum Sonenberg
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14