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Showing 1–4 of 4 results
Advanced filters: Author: Eduard Zorita Clear advanced filters
  • HIV-1 usually targets active genes and integrates near the nuclear pore compartment. Here the authors show that recurrently targeted genes are proximal to super-enhancer genomic elements, which cluster in specific spatial compartments of the T cell nucleus, suggesting a role for nuclear organisation in viral infection.

    • Bojana Lucic
    • Heng-Chang Chen
    • Marina Lusic
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12
  • Both A/B compartments and TADs are thought to be absent from the inactive X chromosome, but to be re-established with transcriptional reactivation and chromatin opening during X-reactivation. Here, the authors characterise gene reactivation, chromatin opening and chromosome topology during X-reactivation, observe A/B-like compartments on the inactive X that guide TAD formation independently of transcription during X-reactivation.

    • Moritz Bauer
    • Enrique Vidal
    • Bernhard Payer
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-21
  • Barcoded HIV ensembles (B-HIVE) provides a new approach to map HIV integration sites and to determine how genomic context influences proviral transcription activity and response to latency-reversing agents.

    • Heng-Chang Chen
    • Javier P Martinez
    • Guillaume J Filion
    Research
    Nature Structural & Molecular Biology
    Volume: 24, P: 47-54