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Showing 1–4 of 4 results

Advanced filters: Author: Edward Ainscow Clear advanced filters

Structure-guided combination therapy to potently improve the function of mutant CFTRs

Targeting different aspects of mutant CFTR structural defects with combination therapy leads to more potent rescue of function than that following single therapy.

Guido Veit
Haijin Xu
Gergely L. Lukacs
Research08 Oct 2018
Nature Medicine

Volume: 24, P: 1732-1742
Correction: The CDK7 inhibitor CT7001 (Samuraciclib) targets proliferation pathways to inhibit advanced prostate cancer

Theodora A. Constantin
Anabel Varela-Carver
Charlotte L. Bevan
Amendments and CorrectionsOpen Access14 Feb 2024
British Journal of Cancer

Volume: 130, P: 892
Suppressors of superoxide production from mitochondrial complex III

High-throughput chemical screening identified several groups of compounds that selectively block superoxide production from the outer Q-binding site of mitochondrial complex III and protect against ROS-induced oxidative stress in pancreatic β cells.

Adam L Orr
Leonardo Vargas
Martin D Brand
Research14 Sept 2015
Nature Chemical Biology

Volume: 11, P: 834-836
The CDK7 inhibitor CT7001 (Samuraciclib) targets proliferation pathways to inhibit advanced prostate cancer

Theodora A. Constantin
Anabel Varela-Carver
Charlotte L. Bevan
ResearchOpen Access19 Apr 2023
British Journal of Cancer

Volume: 128, P: 2326-2337