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Showing 1–3 of 3 results
Advanced filters: Author: Edward J. Miracco Clear advanced filters

  • Glycogen Storage Disease 1a (Gsd1a) is an inherited disorder caused by glucose 6-phosphatase (G6Pase-α) deficiency and characterized by hypoglycaemia and high risk of liver cancer. Here the authors develop a mRNA-based G6Pase-α delivery therapy that is efficacious and safe in a mouse model of GSD1a.

    • Jingsong Cao
    • Minjung Choi
    • Paloma H. Giangrande
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • The long-awaited structure of a telomerase holoenzyme, from Tetrahymena, has been obtained by electron microscopy; affinity labelling of subunits and modelling with NMR and crystal structures of various components allowed the identification of the catalytic core and subunit interactions, and the functional role of the subunits in telomerase processivity was enabled by performing the first reconstitution of the holoenzyme in vitro.

    • Jiansen Jiang
    • Edward J. Miracco
    • Juli Feigon
    Research
    Nature
    Volume: 496, P: 187-192