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Nature Biotechnology (3)
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Showing 1–5 of 5 results

Advanced filters: Author: Edward R Kastenhuber Clear advanced filters

Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants

Improved base editing libraries enable high-throughput functional analysis of single-nucleotide variants in cancer.

Francisco J. Sánchez-Rivera
Bianca J. Diaz
Lukas E. Dow
Research14 Feb 2022
Nature Biotechnology

Volume: 40, P: 862-873
An atlas of substrate specificities for the human serine/threonine kinome

Analysis of the kinase activity of 300 protein Ser/Thr kinases reveals that the substrate specificity of the kinome is substantially more diverse than expected and is driven extensively by negative selectivity

Jared L. Johnson
Tomer M. Yaron
Lewis C. Cantley
ResearchOpen Access11 Jan 2023
Nature

Volume: 613, P: 759-766
Deletions linked to TP53 loss drive cancer through p53-independent mechanisms

The loss of the TP53 gene is often involved in the development of human cancer; here, the deletion of other genes in the vicinity is shown also to contribute to cancer progression in a mouse model.

Yu Liu
Chong Chen
Scott W. Lowe
Research16 Mar 2016
Nature

Volume: 531, P: 471-475
Optimized base editors enable efficient editing in cells, organoids and mice

The efficiency of base editing is substantially increased by optimizing expression and nuclear localization of the editing enzymes.

Maria Paz Zafra
Emma M Schatoff
Lukas E Dow
Research03 Jul 2018
Nature Biotechnology

Volume: 36, P: 888-893
Inducible in vivo genome editing with CRISPR-Cas9

Mouse lines with an inducible Cas9 gene enable in vivo disease modeling.

Lukas E Dow
Jonathan Fisher
Scott W Lowe
Research18 Feb 2015
Nature Biotechnology

Volume: 33, P: 390-394