NMR studies of the lymphoproliferation mutant (V238N) of the Fas death domain indicate that helix 3 is unfolded. This local structural change abolishes binding to FADD — a protein that interacts with Fas and also contains a death domain — and causes the accumulation of autoreactive T cells.
- Matthias Eberstadt
- Baohua Huang
- Stephen W. Fesik
