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Showing 1–2 of 2 results
Advanced filters: Author: Eejung Kim Clear advanced filters

  • NetSig is a network-based statistic that identifies cancer driver genes with high accuracy and can be combined with gene-based statistical tests; results are validated with a large-scale in vivo tumorigenesis assay.

    • Heiko Horn
    • Michael S Lawrence
    • Kasper Lage
    Research
    Nature Methods
    Volume: 15, P: 61-66

  • Large-scale loss-of-function screens and TP53 saturation mutagenesis screens in human cancer cell lines suggest that mutational processes combine with phenotypic selection to shape the landscape of somatic mutations at the TP53 locus.

    • Andrew O. Giacomelli
    • Xiaoping Yang
    • William C. Hahn
    Research
    Nature Genetics
    Volume: 50, P: 1381-1387